Lecithin retinol acyltransferase

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LRAT
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LRAT, LCA14, lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase), lecithin retinol acyltransferase
External IDs MGI: 1891259 HomoloGene: 3483 GeneCards: LRAT
Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for LRAT
Genomic location for LRAT
Band 4q32.1 Start 154,626,945 bp[1]
End 154,753,118 bp[1]
RNA expression pattern
PBB GE LRAT 220317 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001301645
NM_004744

NM_023624

RefSeq (protein)

NP_001288574
NP_004735

NP_076113

Location (UCSC) Chr 4: 154.63 – 154.75 Mb Chr 3: 82.89 – 82.9 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Lecithin retinol acyltransferase is an enzyme that in humans is encoded by the LRAT gene.[5][6]

Function[edit]

Lecithin retinol acyltransferase is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester during phototransduction, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver.

Clinical significance[edit]

Mutations in this gene have been associated with early-onset severe retinal dystrophy.[6]

LRAT was overexpressed in colorectal cancer cells compared to normal colonic epithelium. Strong LRAT expression was associated with a poor prognosis in patients with colorectal cancer.[7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000121207 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028003 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Ruiz A, Winston A, Lim YH, Gilbert BA, Rando RR, Bok D (Feb 1999). "Molecular and biochemical characterization of lecithin retinol acyltransferase". J Biol Chem. 274 (6): 3834–41. doi:10.1074/jbc.274.6.3834. PMID 9920938. 
  6. ^ a b "Entrez Gene: LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)". 
  7. ^ Brown, Gordon; Beatriz Cash; Daniela Blihoghe; Petronella Johansson; Ayham Alnabulsi; Graeme Murray (2014-03-07). "The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer". PLOS ONE. 9: e90776. doi:10.1371/journal.pone.0090776. PMC 3946526Freely accessible. PMID 24608339. 

Further reading[edit]

External links[edit]