Leon County is a county in the Panhandle of the U.S. state of Florida. It was named after the Spanish explorer Juan Ponce de León. As of the 2020 census, the population was 292,198.

Tallahassee is the capital city of the U.S. state of Florida. It is the county seat and only incorporated municipality in Leon County. Tallahassee became the capital of Florida, then the Florida Territory, in 1824. In 2022, the estimated population was 201,731, making it the eighth-most populous city in the state of Florida. It is the principal city of the Tallahassee, Florida Metropolitan Statistical Area, which itself had an estimated population of 390,992 as of 2022. Tallahassee is the largest city in the Florida Big Bend and Florida Panhandle region, and the main center for trade and agriculture in the Florida Big Bend and Southwest Georgia regions.