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List of emperors of Japan

This list of Emperors of Japan presents the traditional order of succession. Records of the reigns of the Emperors of Japan are compiled according to the traditional Japanese calendar. In the nengō system, in use since the late-seventh century, years are numbered using the Japanese era name and the number of years which have taken place since that nengō era started; the sequence and dates of the first 28 Emperors of Japan, the first 16, are based on the Japanese calendar system. Empress TsunuzashiEmperor of Japan Sesshō and Kampaku Shōgun List of shōguns Japanese imperial family tree Ackroyd, Joyce.. Lessons from History: the'Tokushi yoron'. Brisbane: University of Queensland Press. ISBN 9780702214851. Gukanshō: The Future and the Past. Berkeley: University of California Press. ISBN 978-0-520-03460-0. Nihon Ōdai Ichiran. Paris: Royal Asiatic Society, Oriental Translation Fund of Great Britain and Ireland. OCLC 5850691 Varley, H. Paul.. Jinnō Shōtōki: A Chronicle of Gods and Sovereigns. New York: Columbia University Press.

ISBN 978-0-231-04940-5.

Wee Winnie Witch's Skinny

Wee Winnie Witch's Skinny: An Original Scare Tale is a 2004 picture book by Virginia Hamilton and illustrated by Barry Moser. It is about a witch, Wee Winnie, who terrifies Uncle Big Anthony but is killed by Mamma Granny. Booklist, reviewing Wee Winnie Witch's Skinny, wrote "This original scare tale, which may be her creepiest, is a wonderful horror story that draws on traditional beliefs about witches hanging up their skins and riding people using braided hair as a bridle. Moser's framed, colored wood engravings do a great job of bringing the wild, shivery adventure close to home, their black backgrounds and strong lines lit with garish Halloween images in shades of green and red." The School Library Journal recommended that "This tale is admirably suited to Halloween telling, or for any time that shivers are in order."The Horn Book Magazine drew comparisons with Zora Neale Hurston's The Skull Talks Back and wrote that some of the illustrations "reflect a reality of historical suffering" and "casts an eerie suggestion of lynching" It found that "Visually and verbally, this is dark art on dark art."Wee Winnie Witch's Skinny has been reviewed by Publishers Weekly, Kirkus Reviews

Maxime Schwartz

Maxime Simon Schwartz, born on June, 1940 in Blois, is a French molecular biologist, a research director at the CNRS, a professor at the Pasteur Institute and Director General of the Pasteur Institute. He is a correspondant of the French Academy of sciences. Maxime Schwartz was born on 1 June 1940 in Loir-et-Cher, he is the son of Yvonne Berr. His paternal grandparents were Anselme Schwartz and Claire Debré, sister of the pediatrician Robert Debré, his maternal grandparents were Raymond Berr, director of the Kuhlmann Establishment and Antoinette Rodrigues Ely, who died in deportation, their daughter Hélène Berr. With his brother Yves, he is a nephew of Laurent Schwartz and Bertrand Schwartz, his father's brothers. After completing his secondary education at the Lycée Janson-de-Sailly, he entered the École Polytechnique in 1959. A student at this institution until 1961, he did his military service in the Navy in Toulon, where he worked alongside Henri Laborit. In 1962-1963, Maxime Schwartz obtained a mixed degree in physics and biology.

From 1964 to 1967, under the direction of Jacques Monod, at the Pasteur Institute, he prepared a doctorate, which he defended in June 1967. During the preparation of this doctorate he benefited from the advice of François Jacob, with whom he worked for more than thirty years. From 1967 to 1969, as a Junior Fellow of the Harvard Society of Fellows at Harvard University, he carried out a postdoctoral internship in James Watson's laboratory at that university, he spent the last three months of 1969 at the Salk Institute, where he collaborated with Suzanne Bourgeois in the laboratory of Melvin Cohn. After his doctorate, Maxime Schwartz returned to the Pasteur Institute, where he remained for most of his career, he first worked there as a researcher at the CNRS, from 1973, as a CNRS/Institut Pasteur dual member. At the CNRS, he was a research professor from 1971 to 1986 and research director from 1986 to 2007. At the Pasteur Institute, he was head of laboratory from 1973 to 1984 and professor from 1984 to 2007.

From 1975 to 1995, he was head of the Molecular Genetics Unit at the Pasteur Institute. From 1985 to 1987, he was Deputy Director of the Pasteur Institute. From 1988 to 1999, he was Director General of the Pasteur Institute. From 2000 to 2001, he was Head of the Cell Physiology Unit at the Pasteur Institute. Since 2007, the year of his retirement, he has been a chargé de mission with the management of the Institut Pasteur. From 2002 to 2006, he was Scientific Director of the French Food Safety Agency, headed by Martin Hirsch Pascale Briand. On March 30, 1987, Maxime Schwartz was elected correspondant of the French Academy of sciences, in the Molecular and Cellular Biology and Genomics section. S. A. Waksman Gold Medal of the French Academy of sciences. Richard Lounsbery Prize of the French Academy of sciences and the National Academy of Sciences. Officier of the Ordre des Palmes Académiques Commandeur of the Ordre National du Mérite May 2, 2017 Officier of the Légion d'Honneur Commandeur of the Ordre du Lion Commandeur of the Order of the Southern Cross Maxime Schwartz's scientific work concerns various aspects of the metabolism of a sugar, maltose, in the bacterium Escherichia coli.

These have enabled him to address general questions, such as the regulation of protein synthesis and the structure and biogenesis of membrane proteins. François Jacob and Jacques Monod's work on the metabolism of another sugar, lactose, in the same bacterium led them to propose that the expression of genes encoding the enzymes necessary for the metabolism of this sugar is blocked by a repressor, a regulatory protein whose action is itself inhibited in the presence of lactose; the unblocking of the genes thus results from the inhibition of the repressor. This regulation involving a double inhibition was to be qualified as negative. Based on his work on maltose metabolism, Maxime Schwartz was one of the first to suggest the existence of positive regulation, the expression of genes resulting from the activation of an activator. Positive regulation mechanisms subsequently proved to be frequent in all living cells; the most original aspect of Maxime Schwartz's work on membrane proteins is the demonstration that one of the proteins allowing the transport of maltose through the bacterial envelope serves as a receptor for a bacterial virus, the bacteriophage lambda.

It was a novel notion that virus receptors are proteins with a well-defined function for the target cell. This is now a well-established fact for many viruses. Maxime Schwartz has been interested, in collaboration with the laboratory of the American Jonathan Beckwith, in the mechanisms that allow proteins to be placed in various layers of the bacterial envelope. Using genetic methods, he is helping to demonstrate that the signal sequence, located at the amino-terminal end of membrane-through proteins and defined by Gunther Blobel's group, is indeed necessary for the transport of these proteins across the cytoplasm membrane, but is not sufficient. Indeed the inactivation by mutation of the signal sequence prevents such a protein from crossing the membrane. Managing Director of the Institut Pasteur for two consecutive six-year terms, Maxime Schwartz is striving to continue the work of modernization begun by his predecessors, Jacques Monod, François Gros and Raymond Dedonder. On the Paris campus, he presided over the construction of several new buildings, including the