List of recombinant proteins

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The following is a list of notable proteins that are produced from recombinant DNA, using biomolecular engineering.[1] In many cases, recombinant human proteins have replaced the original animal-derived version used in medicine; the prefix "rh" for "recombinant human" appears less and less in the literature. A much larger number of recombinant proteins is used in the research laboratory; these include both commercially available proteins (for example most of the enzymes used in the molecular biology laboratory), and those that are generated in the course specific research projects.

Human recombinants that largely replaced animal or harvested from human types[edit]

Medicinal applications[edit]

Research applications[edit]

  • Ribosomal proteins: For the studies of individual ribosomal proteins, the use of proteins that are produced and purified from recombinant sources[2][3][4][5] has largely replaced those that are obtained through isolation.[6][7] However, isolation is still required for the studies of the whole ribosome.[8][9]
  • Lysosomal proteins: Lysosomal proteins are difficult to produce recombinantly due to the number and type of post-translational modifications that they have (e.g. glycosylation). As a result, recombinant lysosomal proteins are usually produced in mammalian cells.[10] However, recent studies have shown that it may be possible to produce recombinant lysosomal proteins with microorganisms such as Escherichia coli and Saccharomyces cerevisiae.[11] Recombinant lysosomal proteins are used for both research and medical applications, such as enzyme replacement therapy.[12]

Human recombinants with recombination as only source[edit]

Medicinal applications[edit]

Animal recombinants[edit]

Medicinal applications[edit]

Bacterial recombinants[edit]

Industrial applications[edit]

Viral recombinants[edit]

Medicinal applications[edit]

Plant recombinants[edit]

Research applications[edit]

Industrial applications[edit]

References[edit]

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  2. ^ Danilo Correddu, José de Jesús Montaño López, Praveen G. Vadakkedath, Amy Lai, Jane I. Pernes, Paris R. Watson, Ivanhoe K. H. Leung (2019). "An improved method for the heterologous production of soluble human ribosomal proteins in Escherichia coli". Sci. Rep. 9: 8884. doi:10.1038/s41598-019-45323-8. PMC 6586885. PMID 31222068.CS1 maint: Multiple names: authors list (link)
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  5. ^ Marek Tchórzewski, Aleksandra Boguszewska, Dariusz Abramczyk, Nikodem Grankowski (1999). "Overexpression in Escherichia coli, purification, and characterization of recombinant 60S ribosomal acidic proteins from Saccharomyces cerevisiae". Protein Expr. Purif. 15: 40–47. doi:10.1006/prep.1998.0997. PMID 10024468.CS1 maint: Multiple names: authors list (link)
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See also[edit]

External links[edit]