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Locus (genetics)

In genetics, a locus is a specific, fixed position on a chromosome where a particular gene or genetic marker is located. Each chromosome carries many genes, with each gene occupying locus. Genes may possess multiple variants known as alleles, an allele may be said to reside at a particular locus. Diploid and polyploid cells whose chromosomes have the same allele at a given locus are called homozygous with respect to that locus, while those that have different alleles at a given locus are called heterozygous; the ordered list of loci known for a particular genome is called a gene map. Gene mapping is the process of determining the specific locus or loci responsible for producing a particular phenotype or biological trait; the shorter arm of a chromosome is termed the p arm or p-arm, while the longer arm is the q arm or q-arm. The chromosomal locus of a typical gene, for example, might be written 3p22.1, where: 3 = chromosome 3 p = p-arm 22 = region 2, band 2 1 = sub-band 1Thus the entire locus of the example above would be read as "three P two two point one".

The cytogenetic bands are areas of the chromosome either rich in actively-transcribed DNA or packaged DNA. They appear differently upon staining, they are counted from the centromere out toward the telomeres. A range of loci is specified in a similar way. For example, the locus of gene OCA1 may be written "11q1.4-q2.1", meaning it is on the long arm of chromosome 11, somewhere in the range from sub-band 4 of region 1 to sub-band 1 of region 2. The ends of a chromosome are labeled "pter" and "qter", so "2qter" refers to the terminus of the long arm of chromosome 2. Chromosomal translocation Cytogenetic notation Karyotype Null allele International System for Human Cytogenetic Nomenclature Michael, R. Cummings.. Human Heredity. Belmont, California: Brooks/Cole. Overview at Chromosome Banding and Nomenclature from NCBI

Mother lode

Mother lode is a principal vein or zone of gold or silver ore. The term is used colloquially to refer to the real or imaginary origin of something valuable or in great abundance; the term came from a literal translation of the Spanish veta madre, a term common in old Mexican mining. Veta madre, for instance, is the name given to an 11-kilometre-long silver vein discovered in 1548 in Guanajuato, New Spain. In the United States, Mother Lode is most famously the name given to a long alignment of hard-rock gold deposits stretching northwest-southeast in the Sierra Nevada of California, it was discovered during the California gold rush. The California Mother Lode is a zone from 1.5 to 6 kilometres wide and 190 kilometres long, between Georgetown on the north and Mormon Bar on the south. The Mother Lode coincides with the suture line of the Smartville Block; the zone contains hundreds of mines and prospects, including some of the best-known historic mines of the gold-rush era. Individual gold deposits within the Mother Lode are gold-bearing quartz veins up to 15 metres thick and a few thousand feet long.

The California Mother Lode was one of the most productive gold-producing districts in the United States. Now it is known for its vineyards; the California gold rush, as with most gold rushes, started with the discovery of placer gold in sands and gravels of streambeds, where the gold had eroded from the hard-rock vein deposits. Placer miners followed the gold-bearing sands upstream to discover the source in the bedrock; this source was the "mother" of the gold in the river and so was dubbed the "mother lode". Motherlode is a popular cheat code in The Sims. A ski lift at Park City Mountain Resort bears the name “Motherlode”. "Mother Lode" is a legend in Megaman Legends saga, rumored to be a valuable treasure that could provide so much power that the world never need to fear of running out of energy and make the wearer rich. Thom Yorke's second solo album “Tomorrow's Modern Boxes” from 2014 contains a song called “The Mother Lode.” In World Of Warcraft there is a dungeon called "The MOTHERLODE!!".

Alaska Gold Rush California Gold Rush Gold Country Placer mining

Barry Cowan (tennis)

Barry Cowan is a British former tennis player, best known for taking Pete Sampras to five sets at Wimbledon in 2001. Born in Southport, Cowan attended the LTA Rover School at Bisham Abbey, he was a member of Aughton Tennis Club. A left-hander, Cowan was a versatile sportsman in his junior years. After success in junior tournaments, Cowan first competed at the All England Club in 1994 as a wild card, losing in the first round to that year's French Open champion Sergi Bruguera in four sets. Cowan was only to appear in Grand Slams as a Wimbledon wild card; however he was successful in qualifying for the U. S. Open at Flushing Meadows in 2000, though he lost in straight sets to Jens Knippschild. Cowan represented Britain at the Sydney Olympics taking the first set but losing to Daniel Nestor in round one. In 2001, Cowan once again gained a wild card entry into Wimbledon, won his first SW19 singles match in a battle of Britain against Mark Hilton in straight sets, setting up a dream second round match against Sampras, undefeated at Wimbledon since 1996, the match was the epitome of a David & Goliath, with there being 264 places between the two in the World Rankings.

As expected Sampras dominated the first two sets on Court 1, leading 6–3, 6–2 before Cowan came back against all expectations, taking an epic third set tie break. During breaks in play, Cowan would listen to music, notably You'll Never Walk Alone, which can be heard at Anfield home of his team Liverpool FC. Before the match he had sought advice from a top sports psychologist to help prepare himself for the daunting task of facing the world number one; the help seemed to pay off and with the partisan British crowd cheering Cowan on, Cowan upset the form book to break the Sampras serve to win the fourth set 6–4 and take it into a final set. However, all dreams of an upset evaporated as Sampras broke back in the final set to win 6–3, 6–2, 6–7, 4–6, 6–3. In September 2001, Cowan played in his only Davis Cup singles match representing Britain in a World Group Qualifier against Ecuador, he lost in straight sets to Luis Adrijan Moreon 6–1, 6–4, although the result did not affect Britain's performance, as they beat Ecuador 4–1 overall.

Cowan would once again reach the second round at Wimbledon a year bowing out in four sets to Ecuador's Nicolás Lapentti. After that defeat, Cowan announced his retirement from professional tennis. Since retiring from the game, Cowan has taken up a commentating role with Sky Sports for their tennis coverage. Outside the game, Cowan is a keen supporter of Liverpool Football Club. Barry Cowan at the Association of Tennis Professionals Barry Cowan at the International Tennis Federation Barry Cowan at the Davis Cup

Magic: The Gathering core sets, 1993–2007

The collectible card game Magic: The Gathering published nine core sets from 1993–2007 referred to as basic sets and base sets. These sets consisted of reprints focusing on staple cards Wizards of the Coast felt should always be available; these cards were simpler than cards in expansion sets, omitting multicolored cards, used only the original abilities and keywords of Magic such as Flying and Haste. As Magic grew, the base sets were considered descendants of the original Limited Edition, shaped the default setting and feel of Magic. In contrast, Magic "expansion sets" chose a particular theme, such as artifacts for Antiquities. All cards were given a white border to mark them as reprints, with a few exceptions. From Fourth Edition in 1995 onward, a new base set would come out once per two years in the spring or early summer. Early in the history of Magic, the sets sold out nearly instantaneously, supplying the game's growing fan base proved tricky. Sales were concentrated on the West Coast of the United States, where Wizards of the Coast was based.

The earliest base sets—Unlimited and Fourth Edition—helped provide the first experience with Magic for many players in areas where Magic had never been sold before, enabling them to catch up on the base game with cards that, while technically reprints, had never been available to them before. As the market became saturated, the base sets took on a changed role. Seventh Edition, released in 2001, was sold both as a "Basic" and an "Advanced" product, with the expansion sets of the time marked as "Expert." Eighth and Ninth editions were marketed similarly. However, sales were disappointing, an alarming problem for Wizards, as some entry point for newer players was required to keep Magic alive. In 2009, Wizards of the Coast changed their policy for core sets, began making smaller core sets that included new cards, starting with the Magic 2010 set. According to Wizards of the Coast, the previous core sets had "been marginalized by the enfranchised player base", change was required to make the Core Sets of interest to players of all skill levels once more.

Unlimited Edition referred to as Second Edition, was the second Magic: The Gathering set. It was released on December 1, 1993, after Beta had sold out as as Alpha had. Unlimited Edition contains the same cards as Limited Edition Beta, including the Power Nine cards, the three sets are considered as a single set. Unlimited cards have white borders rather than black, however; this precedent that white borders implied a reprint was honored until the 2007 release of Tenth Edition, which returned to black borders. Unlimited was sold in starter packs of 60 cards and booster packs of 15 cards, it was the first set to be titled as something other than just Magic: The Gathering. The "Unlimited Edition" label appears on the booster boxes and booster packs. While it is possible to distinguish Unlimited cards from Revised cards by just looking at the text the cards from both sets are more distinguished by comparing the borders of the cards; the picture frame of Unlimited cards has a beveled edge. Revised Edition was the sixth set and third core set released for Magic: The Gathering.

Like previous core sets, it had no expansion symbol. Revised Edition cards are white-bordered and known for their washed-out look; the set was contained 306 cards. It was the first base set to contain cards from black-bordered sets other than Beta. Printing of Revised began in early April 1994 and continued until April 1995, when Fourth Edition was announced, it is estimated that about 500 million cards of the set were produced, which eliminated the distribution problems of earlier sets. The cards of Revised were still available well into 1996; the cards of Revised like the cards of the preceding Unlimited Edition all had white borders, no expansion symbol, the artist credit at the bottom left. However, the cards were far paler than their Unlimited counterparts, the three-dimensional beveling of the cards was cropped out; this gave the cards an appearance, criticized as "washed out" and unprofessional. The beveling was returned in 4th Edition, the colors were much more vibrant in that set; the large print run meant that Revised basic lands were so numerous and common that it was uncommon to find any other lands in decks until several years later.

The collation of the cards made it possible for a basic land card to appear in the common and uncommon slots of a pack. This was intentional. Basic lands would get their own full print sheets in 4th Edition, making Revised the last tournament-legal set until Seventh Edition in which basic lands could be found in booster packs. Basic lands returned as a card slot in the Shards of Alara block of 2008. One card-printing error of note appeared on the card Serendib Efreet; this blue creature card was misprinted with a green border and a picture of another card, Ifh-Bíff Efreet. The name, mana cost and rules text were all though; the Revised version is now the most common due to the limited print run of the original, intended versions. Revised was the first base edition o

Tal (singer)

Tal Benizri, professionally known by her mononym Tal, is an Israeli-French singer and dancer. She is signed to Warner Music France. Tal Benyerzi was born in Israel, her family immigrated to France before her first birthday. Her name means "morning dew" in Hebrew, she was born into a musical home. Her father was her mother a professional singer under the name Sem Azar, her brother is a songwriter and her aunt and cousin are singers. At the age of 3, Tal enrolled in dance lessons and modern jazz, she took part in a theater group called Compagnie Les Sales Gosses. She started playing in piano bars making interpretations of contemporary songs, her first song and music video was with "La Musique mon ange". After two years of collaboration with songwriter and producer L'Aura Marciano, Tal released her debut album Le droit de rêver with pop melodies, urban rhythm and at times classical arrangements. Collaborations included Sean Paul in "Waya Waya" mixed by Veronica Ferraro, L'Algérino in a remake "Le sens de la vie" and John Hanes as sound engineer.

Her first single from the album was "On avance" which reached No. 29 in SNEP, the official French singles chart. That was followed by "Waya Waya", her biggest hit was "Le sens de la vie" from the album. It reached No. 4 in the French charts. The album contains a bonus version of the song featuring French-Algerian L'Algérino as a bonus track. Tal remains involved in charity, she was the spokesman for MTV's campaign for support of the French AIDS charity Sidaction. Studio albumsLive albums Other releases2012: "Le sens de la vie" Featured in 2014 - Une autre person with Little Mix. Tal has been a member of the Les Enfoirés charity ensemble since 2013. In January 2013, she was nominated for "Francophone revelation of the Year" at the NRJ Music Awards. In December 2013, 2014 and 2016, she won "Francophone Female Artist of the Year" at the NRJ Music Awards. Official website Facebook Twitter TalTV on YouTube

Dallas Cotton Exchange Building

The Dallas Cotton Exchange Building was a 17-story tan brick and concrete building on the corner of North St. Paul and San Jacinto Streets in downtown Dallas, Texas, it was built in 1926 and was for decades Dallas' second-tallest, as the city was growing into the largest inland cotton market in the U. S. By 1971, though the city had become the financial capital of the cotton industry, the exchange housed more Baptists than brokers because of offices rented to nearby First Baptist Church. By 1987 the building sat vacant. New owner James Louis Williams purchased the Cotton Exchange Building in 1985 and planned to tear it down to build a new 52-story tower in its place, but due to the savings and loan crisis that began in the late 1980s, Williams ended up in bankruptcy court, which in 1991 cut his debt on the structure from $15 million to $9.9 million. Meanwhile, the original lender on the building, First RepublicBank Corp. had failed in 1988, sending the loan to the Federal Deposit Insurance Corp.

In 1991, demolition crews were hired to implode the structure. City inspectors determined that the Cotton Exchange's precast concrete panels, attached during a 1960s renovation, had a high asbestos content and should be removed before implosion; when these were removed, it was discovered that the building's original 1926 exterior was intact and efforts were initiated to save the building from implosion. Then-Mayor Steve Bartlett attempted to persuade Mr. Williams to seek a buyer who would convert the offices to apartments, but the Dallas City Council did not pass enhanced tax abatements for inner-city housing renovations until October 1993, too late to stop the process. On June 25, 1994, the building was destroyed by implosion; the site was acquired by First Baptist Church, which in 2013 opened a $115 million state-of-the-art campus on land that includes the former Cotton Exchange Building footprint. The stone lions, a signature architectural detail of the building, now grace the Maple Avenue entrance of the Stoneleigh Hotel