Lupeol synthase

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Lupeol synthase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Lupeol synthase (EC, LUPI, BPW, RcLUS) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, lupeol-forming).[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene lupeol

Also forms some beta-amyrin.


  1. ^ Herrera, J.B.; Bartel, B.; Wilson, W.K.; Matsuda, S.P. (1998). "Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene". Phytochemistry. 49: 1905–1911. doi:10.1016/s0031-9422(98)00366-5. PMID 9883589. 
  2. ^ Shibuya, M.; Zhang, H.; Endo, A.; Shishikura, K.; Kushiro, T.; Ebizuka, Y. (1999). "Two branches of the lupeol synthase gene in the molecular evolution of plant oxidosqualene cyclases". Eur. J. Biochem. 266: 302–307. doi:10.1046/j.1432-1327.1999.00875.x. PMID 10542078. 
  3. ^ Segura, M.J.; Meyer, M.M.; Matsuda, S.P. (2000). "Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol". Org. Lett. 2: 2257–2259. doi:10.1021/ol006016b. PMID 10930257. 
  4. ^ Zhang, H.; Shibuya, M.; Yokota, S.; Ebizuka, Y. (2003). "Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants". Biol. Pharm. Bull. 26: 642–650. doi:10.1248/bpb.26.642. PMID 12736505. 
  5. ^ Hayashi, H.; Huang, P.; Takada, S.; Obinata, M.; Inoue, K.; Shibuya, M.; Ebizuka, Y. (2004). "Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra". Biol. Pharm. Bull. 27: 1086–1092. doi:10.1248/bpb.27.1086. PMID 15256745. 
  6. ^ Guhling, O.; Hobl, B.; Yeats, T.; Jetter, R. (2006). "Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis". Arch. Biochem. Biophys. 448: 60–72. doi:10.1016/ PMID 16445885. 
  7. ^ Basyuni, M.; Oku, H.; Tsujimoto, E.; Kinjo, K.; Baba, S.; Takara, K. (2007). "Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae". FEBS J. 274: 5028–5042. doi:10.1111/j.1742-4658.2007.06025.x. PMID 17803686. 

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