Lupeol synthase

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Lupeol synthase
Identifiers
EC number5.4.99.41
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Lupeol synthase (EC 5.4.99.41, LUPI, BPW, RcLUS) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, lupeol-forming).[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene lupeol

Also forms some beta-amyrin.

References[edit]

  1. ^ Herrera JB, Bartel B, Wilson WK, Matsuda SP (December 1998). "Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene". Phytochemistry. 49 (7): 1905–11. doi:10.1016/s0031-9422(98)00366-5. PMID 9883589.
  2. ^ Shibuya M, Zhang H, Endo A, Shishikura K, Kushiro T, Ebizuka Y (November 1999). "Two branches of the lupeol synthase gene in the molecular evolution of plant oxidosqualene cyclases". European Journal of Biochemistry. 266 (1): 302–7. doi:10.1046/j.1432-1327.1999.00875.x. PMID 10542078.
  3. ^ Segura MJ, Meyer MM, Matsuda SP (July 2000). "Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol". Organic Letters. 2 (15): 2257–9. doi:10.1021/ol006016b. PMID 10930257.
  4. ^ Zhang H, Shibuya M, Yokota S, Ebizuka Y (May 2003). "Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants". Biological & Pharmaceutical Bulletin. 26 (5): 642–50. doi:10.1248/bpb.26.642. PMID 12736505.
  5. ^ Hayashi H, Huang P, Takada S, Obinata M, Inoue K, Shibuya M, Ebizuka Y (July 2004). "Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra". Biological & Pharmaceutical Bulletin. 27 (7): 1086–92. doi:10.1248/bpb.27.1086. PMID 15256745.
  6. ^ Guhling O, Hobl B, Yeats T, Jetter R (April 2006). "Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis". Archives of Biochemistry and Biophysics. 448 (1–2): 60–72. doi:10.1016/j.abb.2005.12.013. PMID 16445885.
  7. ^ Basyuni M, Oku H, Tsujimoto E, Kinjo K, Baba S, Takara K (October 2007). "Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae". The FEBS Journal. 274 (19): 5028–42. doi:10.1111/j.1742-4658.2007.06025.x. PMID 17803686.

External links[edit]