Lysergic acid

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Lysergic acid
Lysergic acid chemical structure.svg
Lysergic acid.png
Names
IUPAC name
7-Methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxylic acid
Other names
6-Methyl-9,10-didehydroergoline-8-carboxylic acid
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.001.302
UNII
Properties
C16H16N2O2
Molar mass 268.32 g·mol−1
Melting point 238 to 240 °C (460 to 464 °F; 511 to 513 K)
Acidity (pKa) pKa1 = 7.80, pKa2 = 3.30 [1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Lysergic acid, also known as D-lysergic acid and (+)-lysergic acid, is a precursor for a wide range of ergoline alkaloids that are produced by the ergot fungus and found in the seeds of Turbina corymbosa (ololiuhqui), Argyreia nervosa (Hawaiian baby woodrose), and Ipomoea tricolor (morning glories, tlitliltzin). Amides of lysergic acid, lysergamides, are widely used as pharmaceuticals and as psychedelic drugs (LSD). Lysergic acid received its name as it was a product of the lysis of various ergot alkaloids.[2]

Total synthesis[edit]

Lysergic acid is generally produced by hydrolysis[3] of natural lysergamides, but can also be synthesized in the laboratory by a complex total synthesis for example by Robert Burns Woodward's team in 1956.[4] An enantioselective total synthesis based on a palladium-catalyzed domino cyclization reaction has been described in 2011 by Fujii and Ohno.[5] Lysergic acid monohydrate crystallizes in very thin hexagonal leaflets when recrystallized from water. Lysergic acid monohydrate, when dried (140 °C at 2 mmHg or 270 Pa) forms anhydrous lysergic acid.

The biosynthetic route is based on the alkylation of the amino acid tryptophan with dimethylallyl diphosphate (isoprene derived from 3R-mevalonic acid) giving 4-dimethylallyl-L-tryptophan which is N-methylated with S-adenosyl-L-methionine. Oxidative ring closure followed by decarboxylation, reduction, cyclization, oxidation, and allylic isomerization yields D-(+)-lysergic acid.[2]

Isomers[edit]

Lysergic acid is a chiral compound with two stereocenters. The isomer with inverted configuration at carbon atom 8 close to the carboxyl group is called isolysergic acid. Inversion at carbon 5 close to the nitrogen atom leads to L-lysergic acid and L-isolysergic acid, respectively. Lysergic acid is listed as a Table I precursor under the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.[6]

Chemical structures of lysergic acid isomers

See also[edit]

References[edit]

  1. ^ Brown, H. C.; et al. (1955). Braude, E. A.; Nachod, F. C., eds. Determination of Organic Structures by Physical Methods. New York, NY: Academic Press. 
  2. ^ a b Schiff, P. L. (Oct 15, 2006). "Ergot and its alkaloids". Am. J. Pharm. Educ. 70 (5): 98. doi:10.5688/aj700598. PMC 1637017Freely accessible. PMID 17149427. 
  3. ^ Martínková, L.; Kren, V.; Cvak, L.; Ovesná, M.; Prepechalová, I. (Nov 17, 2001). "Hydrolysis of lysergamide to lysergic acid by Rhodococcus equi A4". J. Biotechnol. 84 (1): 63–6. doi:10.1016/s0168-1656(00)00332-1. 
  4. ^ Kornfeld, Edmund C.; Fornefeld, E. J.; Kline, G. Bruce; Mann, Marjorie J.; Morrison, Dwight E.; Jones, Reuben G.; Woodward, R. B. (1956). "The Total Synthesis of Lysergic Acid". J. Am. Chem. Soc. 78: 3087–3114. doi:10.1021/ja01594a039. 
  5. ^ Inuki, S.; Iwata, A.; Oishi, S.; Fujii, N.; Ohno, H. (2011). "Enantioselective Total Synthesis of (+)-Lysergic Acid, (+)-Lysergol, and (+)-Isolysergol by Palladium-Catalyzed Domino Cyclization of Allenes Bearing Amino and Bromoindolyl Groups". J. Org. Chem. 76 (7): 2072–2083. doi:10.1021/jo102388e. 
  6. ^ "List of Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances Under International Control" (PDF). International Narcotics Control Board. Archived from the original (PDF) on 2008-02-27.