M-43 is a state trunkline highway in the southwestern and central parts of the US state of Michigan. The highway runs from South Haven to Webberville along an indirect path through both rural areas and larger cities. The trunkline follows five overall segments: a southeasterly track from South Haven to Oshtemo Township, a northerly path to Plainwell, a southeasterly route to Richland, a northeasterly course to the Hastings area and an easterly route through the Lansing area.

Grand Ledge is a city in the U.S. state of Michigan. The city lies mostly within Eaton County, though a small portion extends into Clinton County to the north. The city sits along the Grand River 12.7 miles west of downtown Lansing. The population was 7,786 at the 2010 census. The city is named for its sandstone rock ledges that rise 40 feet (12 m) above the Grand River and are used by recreational rock climbers.