MAPK12

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MAPK12
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAPK12, ERK3, ERK6, P38GAMMA, PRKM12, SAPK-3, SAPK3, ERK-6, MAPK 12, mitogen-activated protein kinase 12
External IDsMGI: 1353438 HomoloGene: 55705 GeneCards: MAPK12
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for MAPK12
Genomic location for MAPK12
Band22q13.33Start50,245,450 bp[1]
End50,261,825 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002969
NM_001303252

NM_013871

RefSeq (protein)

NP_001290181
NP_002960

NP_038899

Location (UCSC)Chr 22: 50.25 – 50.26 MbChr 15: 89.13 – 89.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitogen-activated protein kinase 12 (MAP kinase 12), also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an enzyme that in humans is encoded by the MAPK12 gene.[5]

Function[edit]

Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.[5]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.