MAPK13

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MAPK13
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAPK13, MAPK 13, MAPK-13, PRKM13, SAPK4, p38delta, mitogen-activated protein kinase 13
External IDsMGI: 1346864 HomoloGene: 48133 GeneCards: MAPK13
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for MAPK13
Genomic location for MAPK13
Band6p21.31Start36,127,809 bp[1]
End36,144,524 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002754

NM_011950

RefSeq (protein)

NP_002745

NP_036080

Location (UCSC)Chr 6: 36.13 – 36.14 MbChr 17: 28.77 – 28.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitogen-activated protein kinase 13 (MAPK 13), also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in humans is encoded by the MAPK13 gene.[5]

Function[edit]

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.[5]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.