MOCS3

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MOCS3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMOCS3, UBA4, molybdenum cofactor synthesis 3
External IDsMGI: 1916622 HomoloGene: 6108 GeneCards: MOCS3
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for MOCS3
Genomic location for MOCS3
Band20q13.13Start50,958,826 bp[1]
End50,963,931 bp[1]
RNA expression pattern
PBB GE MOCS3 206141 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014484

NM_001160330

RefSeq (protein)

NP_055299

NP_001153802

Location (UCSC)Chr 20: 50.96 – 50.96 MbChr 2: 168.23 – 168.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Adenylyltransferase and sulfurtransferase MOCS3 is an enzyme that in humans is encoded by the MOCS3 gene.[5][6]

Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. One of the enzymes required for the biosynthesis of MoCo is molybdopterin synthase (MPT synthase). The protein encoded by this gene adenylates and activates MPT synthase. This gene contains no introns. A pseudogene of this gene is present on chromosome 14.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124217 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074576 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Matthies A, Nimtz M, Leimkuhler S (May 2005). "Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry". Biochemistry. 44 (21): 7912–20. doi:10.1021/bi0503448. PMID 15910006.
  6. ^ a b "Entrez Gene: MOCS3 molybdenum cofactor synthesis 3".

Further reading[edit]