MRGPRX2

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MRGPRX2
Identifiers
AliasesMRGPRX2, MGRG3, MRGX2, MAS related GPR family member X2
External IDsMGI: 3588270 HomoloGene: 24986 GeneCards: MRGPRX2
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for MRGPRX2
Genomic location for MRGPRX2
Band11p15.1Start19,054,455 bp[1]
End19,060,681 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001303615
NM_054030

NM_001034868

RefSeq (protein)

NP_001290544
NP_473371

NP_001030040

Location (UCSC)Chr 11: 19.05 – 19.06 MbChr 7: 48.48 – 48.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene.[5][6] Agonists are gyrase inhibitors like ciprofloxacine and non-steroidal neuromuscular blocking agents like atracurium as well as vancomycin. Activation of MRGPRX2 leads to mast cell degranulation with subsequent pseudo-allergic reactions.


See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183695 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074109 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (Sep 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–632. doi:10.1016/S0092-8674(01)00483-4. PMID 11551509. 
  6. ^ "Entrez Gene: MRGPRX2 MAS-related GPR, member X2". 

Further reading[edit]