MYLK3

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MYLK3
Identifiers
AliasesMYLK3, MLCK, MLCK2, caMLCK, myosin light chain kinase 3
External IDsMGI: 2443063 HomoloGene: 35278 GeneCards: MYLK3
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for MYLK3
Genomic location for MYLK3
Band16q11.2Start46,703,369 bp[1]
End46,790,407 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308301
NM_182493

NM_001297612
NM_175441

RefSeq (protein)

NP_001295230
NP_872299

NP_001284541
NP_780650

Location (UCSC)Chr 16: 46.7 – 46.79 MbChr 8: 85.32 – 85.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myosin light chain kinase 3 also known as MYLK3, is an enzyme which in humans is encoded by the MYLK3 gene.[5][6]

Function[edit]

Phosphorylation of cardiac myosin heavy chains (see MYH7B) and light chains (see MYL2) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes.[7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140795 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031698 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: MLCK MLCK protein". 
  6. ^ Seguchi O, Takashima S, Yamazaki S, Asakura M, Asano Y, Shintani Y, Wakeno M, Minamino T, Kondo H, Furukawa H, Nakamaru K, Naito A, Takahashi T, Ohtsuka T, Kawakami K, Isomura T, Kitamura S, Tomoike H, Mochizuki N, Kitakaze M (October 2007). "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): 2812–24. doi:10.1172/JCI30804. PMC 1978424Freely accessible. PMID 17885681. 
  7. ^ Chan JY, Takeda M, Briggs LE, Graham ML, Lu JT, Horikoshi N, Weinberg EO, Aoki H, Sato N, Chien KR, Kasahara H (March 2008). "Identification of cardiac-specific myosin light chain kinase". Circ. Res. 102 (5): 571–80. doi:10.1161/CIRCRESAHA.107.161687. PMC 2504503Freely accessible. PMID 18202317. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.