On May 8, 2006, Iranian President Mahmoud Ahmadinejad sent a missive directly to then United States President George W. Bush that proposed "new ways" to end the dispute over the Islamic Republic's development of nuclear power.

Correspondence between Barack Obama and Ali Khamenei started with direct and confidential letters sent by US President Barack Obama to Iranian leader Ali Khamenei aimed at persuading him to negotiate. Ali Shamkhani, Representative of the Supreme Leader and Secretary of the Supreme National Security Council of Iran, confirmed that his country had responded to some of Barack Obama's letters to the Iranian leader, which focused mainly on the issue of Iran's nuclear program. This was the first time that Iran had confirmed such correspondence with the President of the United States. Earlier, domestic and foreign media reported on Barack Obama's letters to Khamenei, which in one case were confirmed by Hassan Firouzabadi, Chief-of-Staff of the Iranian Armed Forces, as a sign of the US government's realism.