Eosinophil major basic protein shortened to major basic protein is encoded in humans by the PRG2 gene. The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A, C3dg; this protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helmintho-toxin, in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage and bronchospasm in allergic diseases. PRG2 is a 117-residue protein, it is toxic towards bacteria and mammalian cells in vitro. The eosinophil major basic protein causes the release of histamine from mast cells and basophils, activates neutrophils and alveolar macrophages. Structurally the major basic protein is similar to lectins, has a fold similar to that seen in C-type lectins. However, unlike other C-type lectins, MBP does not bind either calcium or any of the other carbohydrates that this family recognize.
Instead, MBP recognises heparan sulfate proteoglycans. Two crystallographic structures of MBP have been determined. Major basic protein has been shown to interact with Pregnancy-associated plasma protein A. Arylsulfatase Eosinophil+Major+Basic+Protein at the US National Library of Medicine Medical Subject Headings Overview of all the structural information available in the PDB for UniProt: P13727 at the PDBe-KB
George "David" Banks is an American political advisor who served in the administrations of US Presidents George W. Bush and Donald Trump, advising on energy policy and climate change, he is the executive vice president of the American Council for Capital Formation, a pro-business think tank. Banks was born in United States, he received BA degrees in history and political science and an MA in economics from the University of Missouri at St. Louis, he graduated with a JD from George Mason University. Before his position at ACCF, Banks was a senior adviser to President George W. Bush on international climate change. For his work on Montreal Protocol issues in the Bush White House, Banks was honored by the Obama Administration in 2009. In 2011-2012, he served as Republican deputy staff director of the U. S. Senate Environment and Public Works Committee, he was a deputy director of the nuclear energy program at the Center for Strategic and International Studies, U. S. State Department diplomat, CIA analyst.
In 2017, Banks became Special Assistant for International Energy and Environment at the National Economic and National Security Councils in the administration of President Donald Trump, a post he held until February 2018. He resigned after failing to qualify for security clearance due to admitting that he had smoked marijuana in 2013, his departure came during several other departures of Trump administration officials for failing to achieve full security clearances. He resumed his role with the ACCF. In April 2018, Banks was named a research fellow at Columbia University, specializing in nuclear power. Banks has been a strong advocate for energy free trade and constructive U. S. engagement with China. "China-bashing in the context of U. S. energy policymaking will only cause Beijing to become more stubborn in the South China Sea and more aggressive in locking up energy supplies around the globe,” he wrote in November 2015. He was critical of the Renewable Fuel Standard, writing in The Washington Times in February 2016 that "The RFS has plagued the country for years by jacking up food and fuel costs.
What's more, it offers zero environmental benefits. Congress should nix this standard before it wreaks more havoc on the country."In November 2017, Banks attended the 2017 United Nations Climate Change Conference. He has spoken in support of the Paris climate agreement, calling it "a good Republican agreement", he has spoken in favor of the Kigali Amendment to the Montreal Protocol's potential to create American jobs
Georges-Eugène Haussmann known as Baron Haussmann, was a French official who served as prefect of Seine, chosen by Emperor Napoleon III to carry out a massive urban renewal program of new boulevards and public works in Paris referred to as Haussmann's renovation of Paris. Critics forced his resignation for extravagance, but his vision of the city still dominates central Paris. Haussmann was born in Paris on 27 March 1809, at 53 Rue du Faubourg-du-Roule, in the Beaujon neighbourhood of Paris, the son of Nicolas-Valentin Haussmann and of Ève-Marie-Henriette-Caroline Dentzel, both of German families, the daughter of a general and a deputy of the National Convention: Georges Frédéric Dentzel, a baron of Napoleon's First Empire, he was the grandson of Nicolas Haussmann, a deputy of the Legislative Assembly and National Convention, an administrator of the department of Seine-et-Oise and a commissioner to the army. He began his schooling at the Collège Henri-IV and at the Lycée Condorcet in Paris, began to study law.
At the same time, he studied music as a student at the Paris Conservatory, as he was a talented musician. He was married on 17 October 1838 in Bordeaux to Octavie de Laharpe, they had two daughters: Henriette, who married the banker Camille Dollfus in 1860, Valentine, who married Vicomte Maurice Pernéty, the chief of staff of his department, in 1865. Valentine divorced Pernéty in 1891, she married Georges Renouard. On 21 May 1831, Haussmann began his career in public administration. Following that post, he became deputy prefect of the Lot-et-Garonne Department at Nérac on 9 October 1832, he became the prefect of the Var Department at Draguignan on 24 January 1849 and prefect of the Yonne Department on 15 May 1850. Louis-Napoleon Bonaparte, the nephew of Napoleon Bonaparte, became the first elected president of France in 1848. In 1850, he started an ambitious project to connect the Louvre to the Hotel de Ville in Paris by extending the Rue de Rivoli and create a new park, the Bois de Boulogne, on the outskirts of the city, but he was exasperated by the slow progress made by the incumbent prefect of the Seine, Jean-Jacques Berger.
Louis-Napoleon was popular, but he was blocked from running for re-election by the constitution of the Second French Republic. While he had a majority of the votes in the legislature at his disposal, he did not have the two-thirds majority needed to change the constitution. At the end of December 1851, he staged a coup d'état, in 1852 declared himself Emperor of the French under the title Napoleon III. A plebiscite in November 1852 overwhelmingly approved Napoleon's assumption of the throne, he soon began searching for a new prefect of the Seine to carry out his Paris reconstruction program; the emperor's minister of the interior, Victor de Persigny, interviewed the prefects of Rouen, Lyon and Bordeaux for the Paris post. In his memoirs, he described his interview with Haussmann: "It was Monsieur Haussmann who impressed me the most, it was a strange thing, but it was less his talents and his remarkable intelligence that appealed to me, but the defects in his character. I had in front of me one of the most extraordinary men of our time.
This audacious man wasn't afraid to show who he was.... He told me all of his accomplishments during his administrative career. I wasn't at all displeased.... It seemed to me that he was the man I needed to fight against the ideas and prejudices of a whole school of economics, against devious people and skeptics coming from the Stock Market, against those who were not scrupulous about their methods. Whereas a gentleman of the most elevated spirit, with the most straight and noble character, would fail, this vigorous athlete... full of audacity and skill, capable of opposing expedients with better expedients, traps with more clever traps, would succeed. I told him about the Paris works and offered to put him in charge." Persigny sent him to Napoleon III with the recommendation that he was the man needed to carry out his renewal plans for Paris. Napoleon made him prefect of the Seine on 22 June 1853, on 29 June, the emperor gave him the mission of making the city healthier, less congested and grander.
Haussmann held this post until 1870. Napoleon III and Haussmann launched a series of enormous public works projects in Paris, hiring tens of thousands of workers to improve the sanitation, water supply and traffic circulation of the city. Napoleon III installed a huge map of Paris in his office, marked with coloured lines where he wanted new boulevards to be. Boulevard system was planned as a mechanism for the easy deployment of troops and artillery, however its main purpose was to help solve the traffic problem in a city and interconnect its landmark buildings, he and Haussmann met every day to discuss the projects and overcome the enormous obstacles and opposition they faced as they built the new Paris. The population of Paris had doubled with no increase in its area. To accommodate the growing population and those who would be forced from the centre by the new boulevards and squares Napoleon III planned to build, he issued a decree annexi
The Archdiocese of Strasbourg is a non-metropolitan archdiocese of the Latin Rite of the Catholic Church in France, first mentioned in 343. It is one of nine archbishoprics in France which have no suffragans and the only one of those to be exempt, i.e. subject to the Holy See in Rome, thus not part of any Metropolitan's province. It is headed by Archbishop Luc Ravel, in office since February 2017; the Diocese of Strasbourg was first mentioned in 343, belonging to the ecclesiastical province of the Archbishopric of Mainz since Carolingian times. Archeological diggings below the current Saint Stephen’s Church, Strasbourg in 1948 and 1956 have unearthed the apse of a church dating back to the late 4th or early 5th century, considered the oldest church in Alsace, it is supposed. The diocese may thus have been founded around 300; the bishop was the ruler of an ecclesiastical principality in the Holy Roman Empire during the Middle Ages and Early Modern period. For this state, see Prince-Bishopric of Strasbourg.
Since the 15th century, the diocesan seat has been the Cathedral of Notre-Dame de Strasbourg. By the Concordat of 1801, the Diocese of Strasbourg became a public-law corporation of cult and the diocesan ambit of Strasbourg was redrawn and all its areas east of the river Rhine were redeployed, forming a part of the Archdiocese of Freiburg since 1821. On 29 November 1801 it gained territory from the Diocese of Basel, Diocese of Metz and Diocese of Speyer. On 25 February 1803 it lost territory to the Diocese of Konstanz, on 26 April 1808 it gained territory from the same and in 1815 lost territory to that Diocese of Konstanz. In 1871 the bulk of the diocese became part of German Empire, while small fringes remained with France. On 10 July 1874 Strasbourg diocese, with its diocesan ambit reconfined to the borders of German Alsace, gaining territory from the Diocese of Saint-Dié, losing territory to the Metropolitan Archdiocese of Besançon, it became an exempt diocese subject to the Holy See instead of part of any ecclesiastical province.
When the 1905 French law on the Separation of the Churches and the State was enacted, doing away with public-law religious corporations, this did not apply to the Strasbourg diocese, being within Germany. After World War I, Alsace along with the diocese was returned to France, but the status from the concordat has been preserved since as part of the Local law in Alsace-Moselle; the diocese was elevated to Archdiocese of Strasbourg on 1 June 1988 by Pope John Paul II but not as Metropolitan of an ecclesiastical province and remains exempt, so having nor being a suffragan. The bishop of this see is appointed by the French president according to the Concordat of 1801; the concordat further provides for the clergy being paid by the government and Catholic pupils in public schools can receive religious instruction according to archdiocesan guide lines. It enjoyed papal visits from Pope John Paul II in October 1988 and Pope Francis in November 2014; the archiepiscopal cathedral seat is the Cathedral of Notre Dame in Strasbourg, Grand Est, France, as mother church, a World Heritage Site.
It has four other Minor Basilicas, two in each of the former Alsace region's departments: Basilique du Sacré-Cœur in Lutterbach, Haut-Rhin Basilique Notre-Dame de Marienthal, Bas-Rhin Basilique Notre-Dame de Thierenbach, in Jungholtz, Haut-Rhin Basilique Notre-Dame du Mont Sainte-Odile in Ottrott, Bas-Rhin. As per 2014, it pastorally served 1,380,000 Catholics on 8,280 km² in 767 parishes and 5 missions with 722 priests, 80 deacons, 1,332 lay religious and 17 seminarians; as of 31 December 2003, the area of the archdiocese comprised a total of 1,713,416 inhabitants of which 75.9% are Catholics, divided in 762 parishes covering an area of 8,280 km². 619 diocese priests, 50 deacons, 288 ordained priests and 1,728 nuns belonged to the archdiocese. Suffragan bishops of Strasbourg Amawich Werner de Bavière Guillaume Hermann Werner Thiepald Otton de Hohenstaufen Balduin Cunon Bruno Eberhard Bruno de Hohenberg Gebhard Burchard Rodolphe Father Conrad de Geroldseck Henri de Hasebourg Conrad de Hunebourg Henri de Veringen Berthold de Teck Henri de Stahleck Gautier de Geroldseck Henri de Geroldseck Father Conrad de Lichtenberg Frédéric de Lichtenberg Jean de Dirpheim.
Malé Dvorníky is a village and municipality in the Dunajská Streda District in the Trnava Region of south-west Slovakia. The municipality lies at an altitude of 115 metres and covers an area of 6.885 km². In the 9th century, the territory of Malé Dvorníky became part of the Kingdom of Hungary, it was an Avar settlement in the 6th century. The name of the village was first recorded in 1254 as "Odour"; until the end of World War I, it was part of Hungary and fell within the Dunaszerdahely district of Pozsony County. After the Austro-Hungarian army disintegrated in November 1918, Czechoslovak troops occupied the area. After the Treaty of Trianon of 1920, the village became part of Czechoslovakia. In November 1938, the First Vienna Award granted the area to Hungary and it was held by Hungary until 1945. After Soviet occupation in 1945, Czechoslovak administration returned and the village became part of Czechoslovakia in 1947. In 1946, a great number of local Hungarian families were deported to the Czech lands, but most of them were able to return later.
In 1910, the village had 445, for Hungarian inhabitants. At the 2001 Census the recorded population of the village was 894 while an end-2008 estimate by the Statistical Office had the villages's population as 1036; as of 2001, 92,51 per cent of its population was Hungarian. Roman Catholicism is the majority religion of the village, its adherents numbering 87.58% of the total population
Sir David Charles Calcutt QC was an eminent barrister and public servant, knighted in 1991. He was the Master of Magdalene College, Cambridge from 1985-94, he was responsible for the creation of the Press Complaints Commission. He is buried in the churchyard of St Beuno's Church at Somerset. A chorister in the choir of Christ Church Cathedral, Oxford he attended Christ Church Cathedral School and went on to Cranleigh School; as an undergraduate at the University of Cambridge he was a choral scholar in the Choir of King's College, Cambridge. Calcutt was known throughout the 1980s and 1990s for preparing reports and inquiries into various areas of public life, he was asked to produce a report on a fire in the Falkland Islands in which eight people died soon afterwards to produce a report into the Cyprus Seven spy affair, in which seven servicemen were acquitted of having passed secrets to the Russians. He is most famous for suggesting the creation of the Press Complaints Commission in 1990, though he was quite scathing about it describing it as He was married to Barbara, a psychiatric worker, in 1969, in life, he developed Parkinson's disease, but he remained "cheerful and genial"