Man's Best Friend is a 1993 American science fiction horror film, directed and written by John Lafia. It stars Ally Sheedy, Lance Henriksen, Robert Costanzo, Frederic Lehne, John Cassini, and J. D. Daniels.

Alexandra Elizabeth Sheedy is an American actress. She made her feature film debut in Bad Boys (1983) and came to prominence as a member of the Brat Pack with roles in Oxford Blues (1984), The Breakfast Club (1985), St. Elmo's Fire (1985), and Blue City (1986). She received three Saturn Award nominations for Best Actress for her performances in WarGames (1983), Fear (1990), and Man's Best Friend (1993). For playing a drug-addicted lesbian photographer in High Art (1998), Sheedy won the Independent Spirit Award for Best Female Lead. She also starred in the films Twice in a Lifetime (1985), Short Circuit (1986), Betsy's Wedding (1990), Only the Lonely (1991), and Life During Wartime (2009), as well as the series Single Drunk Female (2022–2023).