Narayanaswamy Srinivasan is an Indian molecular biophysicist and a professor and the head of Proteins: Structure and Evolutionary Group at the Molecular Biophysics Unit of the Indian Institute of Science. He is known for his researches in the fields of computational genomics and protein structure analysis. An elected fellow of the Indian Academy of Sciences and the National Academy of Sciences, India, he is a J. C. Bose National fellow of the Department of Biotechnology and a recipient of the National Bioscience Award for Career Development of the Department of Science and Technology; the Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2007, for his contributions to biological sciences. N. Srinivasan, born on the April Fool's Day of 1962 in Chennai in the south Indian state of Tamil Nadu, graduated in physics from the University of Madras in 1982 and continued at the university to complete his master's degree in biophysics at the Department of Crystallography and Biophysics in 1984.
Joining the Indian Institute of Science, he secured a PhD in 1991 for his thesis, Conformational studies on globular proteins: Data analysis, served as a senior research fellow at IISc, assisting Padmanabhan Balaram, a noted biochemist and Padma Bhushan recipient. His stint at Balaram's laboratory lasted only 10 months and in October 1991, he moved to the Department of Crystallography at Birkbeck College to work with Tom Blundell and stayed there till 1994 when he shifted his base to Ludwig Institute for Cancer Research where he had the opportunity to work under Mike Waterfield. Two years he was reunited with Tom Blundell at the Department of Biochemistry of the University of Cambridge and completed his post-doctoral studies there in May 1998. Srininvasan returned to India the same year and joined the Indian Institute of Science to serve at the Molecular Biophysics Unit as an assistant professor and a senior fellow of the Wellcome Trust. In 2010, he was promoted as a professor and he heads the Proteins: Structure and Evolutionary Group, popularly known as N. S. Group, of the MBU.
In between, he served as an honorary research fellow at Birkbeck College from 1998 to 2000 and is a visiting professor at University of La Réunion, a senior fellow at Manchester University and a visiting professor of Bioinformatics at University of Nantes. Srinivasan's researches were broadly on protein evolution with regard to its structure and interactions, he worked on cellular signal transduction pathways and proteins involved in the process through modeling and computational studies. Deploying computational genomics, he is known to have assisted in identifying similar proteins with shared structural and functional features, his research findings have been published in several articles. He has been granted patents for two of his inventions related to nucleotide sequences, his ongoing project, Multi-macromolecular assemblies, relates to 3-D structures of large macromolecular machines. Srinivasan is a former member of the committee on Affiliates and Special Interests Group of the International Society for Computational Biology and a member of the Structural Biology and Structural Genomics section of the Faculty of 1000.
He is associated with several science journals. He was associated with PRIB 2007, an international conference on Pattern Recognition In Bioinformatics, held in Singapore in 2007 as a member of the program committee and has delivered several featured lectures and keynote addresses which included the Keystone Symposium on Multiprotein Complexes, Asia-Pacific Bioinformatics Conference. On the academic front, he has served as the thesis examiner for a number of Indian universities and as the coordinator of integrated doctoral and BS programs in Biology of Indian Institute of Science, he sits in the Scientific Advisory Board of Jubilant Biosys, a research and development firm involved in drug discovery services. The Department of Biotechnology of India awarded Srinivasan the National Bioscience Award for Career Development in 2004; the year 2007 brought him the Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards, as well as the elected fellowship of the Indian Academy of Sciences and the National Academy of Sciences, India.
He holds the Honorary Research Fellowship of Birkbeck College and the International Senior Fellowship of the Wellcome Trust. Mark S Johnson, Narayanaswamy Srinivasan, Ramanathan Sowdhamini, Tom L Blundell. "Knowledge-based protein modeling". Critical Reviews in Biochemistry and Molecular Biology. 29: 1–68. Doi:10.3109/10409239409086797. CS1 maint: multiple names: authors list KG Tina, Rana Bhadra, Narayanaswamy Srinivasan. "PIC: protein interactions calculator". Nucleic Acids Research. 35: W473–W476. Doi:10.1093/nar/gkm423. PMC 1933215. PMID 17584791. CS1 maint: multiple names: authors list Jonas Emsley, Helen E
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