Marneral synthase

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Marneral synthase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Marneral synthase (EC is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, marneral-forming).[1] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene marneral

Marneral is a triterpenoid formed by Grob fragmentation of the A ring of 2,3-epoxy-2,3-dihydrosqualene during cyclization. This aldehyde gains its name from its structural similarity to a class triterpenes commonly found in members of the Iridaceae, originally identified by Dr. Franz-Josef Marner[1]

This enzyme is a member of a metabolic gene cluster along with two other cytochrome P450s.[2]


  1. ^ a b Xiong Q, Wilson WK, Matsuda SP (February 2006). "An Arabidopsis oxidosqualene cyclase catalyzes iridal skeleton formation by Grob fragmentation". Angewandte Chemie. 45 (8): 1285–8. doi:10.1002/anie.200503420. PMID 16425307. 
  2. ^ Field B, Fiston-Lavier AS, Kemen A, Geisler K, Quesneville H, Osbourn AE (September 2011). "Formation of plant metabolic gene clusters within dynamic chromosomal regions". Proceedings of the National Academy of Sciences of the United States of America. 108 (38): 16116–21. doi:10.1073/pnas.1109273108. PMC 3179108Freely accessible. PMID 21876149. 

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