Ena/Vasp homology proteins
'ENA/VASP Homology proteins' or'EVH' proteins are a family of related proteins involved in cell motility in vertebrate and invertebrate animals. EVH proteins are modular proteins that are involved in actin polymerization, as well as interactions with other proteins. Within the cell, Ena/VASP proteins are found at the leading edge of Lamellipodia and at the tips of filopodia. Ena, the founding member of the family was discovered in a drosophila genetic screen for mutations that act as dominant suppressors of the abl non receptor tyrosine kinase. Invertebrate animals have one Ena homologue, whereas mammals have three, in mice named Mena, VASP, Evl. Ena/VASP proteins promote the spatially regulated actin polymerization required for efficient chemotaxis in response to attractive and repulsive guidance cues. Mice lacking functional copies of all three family members display pleiotropic phenotypes including exencephaly, failures in neurite formation, embryonic lethality. A sub-domain of EVH is the EVH1 domain.
Vasodilator-stimulated phosphoprotein 45-residue-long tetramerization protein domain which regulates actin dynamics in the cytoskeleton. This is vital for processes such as cell migration. Vasodilator-stimulated phosphoprotein is an actin cytoskeletal regulatory protein. VASP is found in dynamic actin structures like filopodia and lamellipodia, but its precise function in their formation is controversial. VASP accelerates filament elongation by delivering monomeric actin to the growing barbed end; the structure is a right-handed alpha helical coiled-coil structure
Mena is a city in Chernihiv Oblast of Ukraine. It serves as the administrative center of Mena Raion. Population: 12,004 The murder of the Jews of Mena during World War II, at Yad Vashem website
American Made (film)
American Made is a 2017 American biographical black comedy crime film directed by Doug Liman, written by Gary Spinelli, starring Tom Cruise, Domhnall Gleeson, Sarah Wright, Alejandro Edda, Mauricio Mejía, Caleb Landry Jones, Jesse Plemons. The plot focuses on Barry Seal, a former TWA pilot who flew missions for the CIA, became a drug smuggler for the Medellín Cartel in the 1980s. In order to avoid jail time, Seal became an informant for the DEA; the film was first released in Taiwan on August 18, 2017, in the United States on September 29, 2017. It is the first film directed by Liman to be released by Universal Pictures since The Bourne Identity in 2002, played in 2D and IMAX in select theaters, it grossed $134 million worldwide against a budget of $50 million, received positive reviews from critics, who praised Cruise's performance. In 1978, Baton Rouge pilot Barry Seal, who flies commercial jets for TWA, is recruited by a CIA case officer calling himself Monty Schafer, he asks Seal, smuggling Cuban cigars into the country via Canada, to fly clandestine reconnaissance missions for the CIA over Central America using a small plane with cameras installed.
At first Seal's wife Lucy thinks he's still with TWA, but she is excited by the wealth generated by his "new company". In the 1980s, Schafer asks Seal to start acting as a courier between the CIA and General Noriega in Panama. During a mission, the Medellín Cartel picks Seal up and asks him to fly cocaine on his return flights to the United States. Seal starts flying the cartel's cocaine to Louisiana; the CIA turns a blind eye to the drug smuggling. To avoid the authorities, Schafer moves Seal and his family to the remote town of Mena, which becomes the hub of all U. S. cocaine trafficking. Schafer asks Seal to run guns to the Nicaraguan Contras based in Honduras. Seal soon realizes that the Contras are not serious about the war and just want to get rich and he starts trading the guns to the cartel; the CIA sets up a Contra training base in Mena and Seal flies the Contras in, but many of them escape as soon as they arrive. Seal makes so much money. Seal's freeloading brother-in-law JB moves in, he starts stealing money from the Seals and is arrested after Sheriff Downing catches him with a briefcase full of laundered cash.
With JB out on bail, Seal gives him money and a plane ticket to Bora Bora and tells him to get lost for his own safety. JB insults Lucy. Barry chases after him but JB's car explodes in a fireball; the CIA shuts the program down and abandons Seal, arrested by the FBI, DEA, ATF and Arkansas State Police simultaneously. Seal escapes prosecution by making a deal with the White House, which wants evidence of the Sandinistas being drug traffickers, they ask Seal to get photos. Seal manages to get the pictures, but the White House releases them as propaganda against the Sandinistas. Seal is prominently shown in the pictures, which leads to his arrest, to the cartel plotting revenge. Seal is convicted but given a light sentence, a total of 1,000 hours community service for the Salvation Army. Moving from motel to motel fails as a way of remaining in hiding because the community service is performed at the same building every night. Assassins sent by Pablo Escobar and the cartel locate Seal and kill him.
After Seal is dead and the evidence is destroyed, the CIA still becomes embroiled in the infamous Iran–Contra affair. Tom Cruise as Barry Seal Sarah Wright as Lucy Seal Domhnall Gleeson as Monty Schafer Alejandro Edda as Jorge Ochoa Benito Martinez as James Rangel Mauricio Mejia as Pablo Escobar Jayma Mays as Dana Sibota Jesse Plemons as Sheriff Joe Downing Lola Kirke as Judy Downing Frank Licari as ATF Special Agent Franks Jed Rees as Louis Finkle Caleb Landry Jones as JB Connor Trinneer as George W. Bush Robert P. Farrior as Oliver North In the summer of 2013, screenwriter Gary Spinelli was looking for a project, based on real events. On the bonus feature of American Made, Spinelli said: I was looking for little hidden pieces of history. Small stories that affected larger global events and I came across the Mena story, and I always wanted to do a gangster film. Goodfellas is one of my favorite movies and I was always on the hunt to try to find my version of that, and once I started researching CIA's involvement in Mena, the same name kept popping up, was this Barry Seal character.
As soon as I found Barry, I knew. The film was titled Mena and was first featured on The Black List, a website showcasing the best unproduced screenplays, in 2014. Principal photography on the film began on May 2015 in Georgia. Filming locations there include counties Cherokee, Clayton, DeKalb, Gwinnett and Pickens. On August 20, 2015, Tom Cruise arrived in Medellin, on August 31, in Santa Marta, to scout filming locations for the film. A plane crash on the set of the film in Colombia on September 11, 2015 killed two people and caused serious injuries to another member of the crew; the plane, carrying crew members, was returning to Enrique Olaya Herrera Airport in Medellín when it ran into bad weather and the crash occurred. The dead were identified as Carlos Berl and Alan Purwin, the founder and president of Helinet Aviation, a company which provides aerial surveillance technology to government agencies and law enforcement, a film pilot who
Mena Station is a railway station in Rankoshi, Isoya District, Hokkaidō, Japan. Hokkaido Railway Company Hakodate Main Line Station S28
Abu Mena was a town, monastery complex and Christian pilgrimage centre in Late Antique Egypt, about 50 km southwest of Alexandria. Its remains were designated a World Heritage Site in 1979. There are few standing remains, but the foundations of most major buildings, such as the great basilica, are discernible. Recent agricultural efforts in the area have led to a significant rise in the water table, which has caused a number of the site's buildings to collapse or become unstable; the site was added to the list of World Heritage in Danger in 2001. Authorities were forced to place sand in the bases of buildings that are most endangered in the site. Menas of Alexandria was martyred in early 4th century. Various 5th-century and accounts give differing versions of his burial and the subsequent founding of his church; the essential elements are that his body was taken from Alexandria on a camel, led into the desert beyond Lake Mareotis. At some point, the camel refused to continue walking, despite all efforts to goad it.
This was taken as a sign of divine will, the body's attendants buried it on that spot. Most versions of the story state that the location of the tomb was forgotten until its miraculous rediscovery by a local shepherd. From the Ethiopian Synaxarium: And God wished to reveal the body of Saint Mînâs, and there was in that desert a certain shepherd, one day a sheep, suffering from the disease of the scab went to that place, dipped himself in the water of the little spring, near the place, he rolled about in it and was healed straightway. And when the shepherd saw this thing, understood the miracle, he marvelled exceedingly and was astonished, and afterwards he used to take some of the dust from that shrine, mix it with water, rub it on the sheep, if they were ill with the scab, they were straightway healed thereby. And this he used to do at all times, he healed all the sick who came to him by this means. Word of the shepherd's healing powers spread rapidly; the synaxarium describes Constantine I sending his sick daughter to the shepherd to be cured, credits her with finding Menas' body, after which Constantine ordered the construction of a church at the site..
By the late 4th century, it was a significant pilgrimage site for Christians who sought healing and other miracles. Menas flasks are a particular type of small terracotta ampullae sold to pilgrims as containers for holy water or holy oil which are found widely around the Western Mediterranean, dating from the century and a half before the Muslim conquest, they are cheaply made but impressed with images of the saint that are of significance in the study of iconography. During the reign of Arcadius, the local archbishop observed that crowds were overwhelming the small church, he wrote to the eastern emperor, who ordered a major expansion of the facilities, the first of three major church expansions which would take place. By the end of the Late Antique period, Abu Mena had become the leading pilgrimage site in Egypt; the site was first excavated from 1905 to 1907. These efforts uncovered a large basilica church, an adjacent church which had housed the saint's remains, Roman baths. A long-term series of excavations by the DAI ended in 1998.
The most recent excavations uncovered a large dormitory for poor pilgrims, with separate wings for men and for women and children. A complex to the south of the great basilica was the residence of the hegoumenos, or abbot. Excavations suggest that the great xenodocheion, a reception area for pilgrims, may have been a cemetery. A baptistery, adjacent to the site of the original church, appears to have gone through at least three phases of development. Uncovered was a complex of wine presses, including underground storage rooms, which dates to the 6th and 7th centuries; the site of Abu Mena was added to UNESCO's World Heritage in Danger list in 2001 due to the threat of rising local water tables. This rise in water is due to agricultural development programs aimed at reclaiming the land; the hard clay soil that surrounds the site can support buildings. However, it becomes unstable when wet and has led to the collapse of cisterns and other structures about the ancient city; as the ground collapses, large cavities form enveloping the overlying structures.
Immediate action was taken to fill the bases of important sites with sand and close them off to the public. In attempts to counteract this phenomenon, the Supreme Council of Antiquities spent 45 million digging trenches and adding pumps in hopes of decreasing the pressure of irrigation. In addition, a fence was added to prevent threat; these proved to be successful and the site was removed from UNESCO’s World Heritage in Danger list in 2009. Since water has continued to rise and cause destruction of monuments; the site is once again on UNESCO’s World Heritage in Danger list. Factors found to negatively impact the property most in 2018 include housing, management activities, managements systems/plan, water; the Egyptian government has implemented emergency plans and indeed solve problem with water table, but the government does not have a thorough management plan or anything related to it. Since UNESCO requires a management plan for all the cultural and natural sites. Several proposals were made.
The most reliable option is the use
Mena is a hamlet in the parish of Lanivet in mid Cornwall, England. It should not be confused with Menna in the parish of Ladock
Niger national football team
The Niger national football team represents Niger in international association football through the Nigerien Football Federation, a member of Confederation of African Football. Niger plays in the colors of the flag of Niger, white and orange, their nickname comes from the Dama gazelle, native to Niger, the Hausa name of, Meyna or Ménas The Dama appears on their badge in the colors of the national flag. Although one of the weaker sides in the strong West Africa region, Niger has produced a couple of noteworthy runs in qualifying tournaments. One of their best performances was in the 1982 FIFA World Cup qualifiers in which Niger eliminated Somalia and Togo on the away goals rule, but were beaten by Algeria in the third round where only eight teams were left. Notable players in this run included Hassane Adamou and Moussa Kanfideni. In 1990, they set a record by thrashing Mauritania 7–1 in continental qualifiers, the highest positive score margin for the Mena. In the 2004 African Nations Cup qualifiers, Niger won all their home games to finish on nine points, just three short of qualification.
The Niger squad is plagued by financial concerns, which have caused them to withdraw from international tournaments on more than one occasion. The Nigerien Football Federation would have turned to fundraising to pay for their trip to the 2010 African Cup of Nations in Angola, had they qualified. In June 2008, Romanian coach Dan Anghelescu took over as team manager from Hamey Amadou, dismissed. Anghelescu had been coaching in Africa since 1999, training teams from Algeria and Burkina Faso. On 19 December 2008, Anghelescu was dismissed after a disastrous six-month spell. Former Niger U-17 coach Frederic Costa was appointed the new head coach of the Niger national side. Harouna Doula Gabde, a former Nigerien international, succeeded them in 2009. On 10 October 2010, Niger earned a shock 1–0 win over Egypt at home in the 2012 African Cup of Nations qualification. Despite a failed run for ACON 2010, Niger hosted and won the UEMOA Tournament in November 2010, followed up with their first qualification for the African Nations Championship in February 2011.
After home wins—as well as away losses—over South Africa and Sierra Leone, on 8 October 2011 Niger qualified for the Africa Cup of Nations for the first time in its history, despite losing 3–0 in Egypt. Niger, South Africa and Sierra Leone all ended with nine points, but Niger qualified thanks to their superior head-to-head record against their rivals. At the 2012 African Cup of Nations, Niger was placed in Group C alongside co-hosts Gabon and Morocco. In their opening match, Niger lost 2–0 to Gabon, while against Tunisia in Libreville, Niger trailed 1–0 on an early goal from Youssef Msakni in which he dribbled his way through for a fine goal after just four minutes. William N'Gounou, however made history by scoring Niger's first goal at the African Cup of Nations. A 1–1 draw looked but Issam Jemâa's goal would eliminate Niger from the tournament. In the final match, Niger faced Morocco in a match featuring two sides eliminated from the tournament. Younès Belhanda scored on an assist from Marouane Chamakh just 11 minutes from time to give Morocco a 1–0 victory.
In 2012, Niger repeated its success in African Nations Cup qualifiers by beating Guinea in a two-legged series to qualify for the 2013 Africa Cup of Nations. Guinea won the first match 1 -- 0. Goalscorers Mohamed Chikoto and Issoufou Boubacar had sent Niger to another African Cup of Nations tournament. In their first match at the 2013 Africa Cup of Nations, Niger lost to Mali at the Nelson Mandela Bay Stadium in Port Elizabeth. Mali captain Seydou Keita handed his nation the hard-fought victory five minutes before the end of the encounter. Niger earned their first point at the African Cup of nations after holding DR Congo to a 0–0 draw. In the third match, Ghana outclassed Niger 3–0 to reach the quarter-finals as Group B winners. Niger finished bottom of the group. On 22 May 2014, Niger played a friendly match against Ukraine, marking the first match against a European nation. Oumarou Bale scored in the 56th minute, cancelling out a 20th-minute goal from Ivan Ordets before Ukraine won on a goal from Taras Stepanenko as the match finished 2–1.
As of 23 March 2019Niger beat Burkina Faso 1–0 in a match played on 27 July 2013, but because of losing the first match 1–0, this match went to extra time and the penalties. Niger lost 6 -- 5 on penalties. Match versus Libya in November 2010 finished 1 -- 1. Under the rules of association football and the official European Championship tournament regulations, a loss inflicted via a penalty shootout does not count as a defeat, but rather a tie which needed a final process to determine the team which advances. Win Draw Loss The following players have been selected for the AFCON qualifier match against Egypt on 23 March 2019. Caps and goals updated as of 23 March 2019 after the game against Egypt; the following players have been called up for Niger in the last 12 months. As of 30 March 2019 Players in bold text are still active with Niger. Heinz-Peter Überjahn Tiemogo Soumaila David Nadjadoum Tiemogo Soumaïla Amadou Touré Patrice Neveu Jean-Yves Chay Harouna Doula Amadou Yeo Martial Bana Tchanile Hamey Amadou Dan Anghelescu Frederic Costa Harouna Doula Gabde Rolland Courbis Gernot Rohr Cheick Omar Diabate François Zahoui Niger Football Federation website