Mesquite is a city in Clark County, Nevada, United States adjacent to the Arizona state line and 80 miles (130 km) northeast of Las Vegas on Interstate 15. As of the 2020 census, the city had a population of 20,471. The city is located in the Virgin River valley adjacent to the Virgin Mountains in the northeastern part of the Mojave Desert. It is home to a growing retirement community, as well as several casino resorts and golf courses.

Clark County is a county located in the U.S. state of Nevada. The land area of Clark County is 8,061 square miles (20,880 km2), or roughly the size of New Jersey. As of the 2020 census, the population was 2,265,461. Most of the county population resides in the Las Vegas Census County Divisions, which has 2,196,623 people as of the 2020 Census. It is by far the most populous county in Nevada, and the 11th-most populous county in the United States. It covers 7% of the state's land area but holds 73% of the state's population, making Nevada the most centralized state in the United States.