Mesulergine

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Mesulergine
Mesulergine.svg
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEBI
ChEMBL
Chemical and physical data
Formula C18H26N4O2S
Molar mass 362.49 g/mol
3D model (JSmol)
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Mesulergine is a psychoactive drug of the ergoline chemical class that acts on serotonin and dopamine receptors.[1][2]

The compound had entered clinical trials for the treatment of Parkinson's disease; however, further development was halted due to adverse histological abnormalities in rats.[3]

See also[edit]

References[edit]

  1. ^ Closse A (May 1983). "[3H]-Mesulergine, a selective ligand for serotonin-2 receptors". Life Sci. 32 (21): 2485–95. doi:10.1016/0024-3205(83)90375-2. PMID 6855451. 
  2. ^ Markstein R (November 1983). "Mesulergine and its 1,20-N,N-bidemethylated metabolite interact directly with D1- and D2-receptors". Eur. J. Pharmacol. 95 (1-2): 101–7. doi:10.1016/0014-2999(83)90272-8. PMID 6230246. 
  3. ^ Dupont E, Mikkelsen B, Jakobsen J (April 1986). "Mesulergine in early Parkinson's disease: a double blind controlled trial". J. Neurol. Neurosurg. Psychiatry. 49 (4): 390–5. doi:10.1136/jnnp.49.4.390. PMC 1028763Freely accessible. PMID 3517235.