Methyldibromo glutaronitrile

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Methyldibromo glutaronitrile
Structural formula of methyldibromo glutaronitrile
IUPAC name
Other names
2-Bromo-2-(bromomethyl) glutaronitrile
Euxyl K400
Tektamer 38
Merquat 2200
Metacide 38
3D model (JSmol)
ECHA InfoCard 100.047.877
EC Number 252-681-0
Molar mass 265.933
Appearance white to yellow crystals
Melting point 51.2 to 52.5 °C (124.2 to 126.5 °F; 324.3 to 325.6 K)
Boiling point 212 °C (414 °F; 485 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Methyldibromo glutaronitrile (MDBGN) is a widely used preservative.

It is made by reacting bromine with 2-methyleneglutaronitrile below 30 °C. An allergy to the chemical can be discovered by performing a patch test.

History and allergy[edit]

In the mid-1980s, a maximum concentration of 0.1% in stay-on and rinse-off cosmetics was allowed.[1] It was discovered soon afterwards that it caused allergic contact dermatitis to people with eczema.[1]

It has been in use since the 1990s as a preservative in skin care products such as lotions, wet wipes, shampoo, and liquid soaps. Industrial applications include its use in preserving oils, glues, and medical gels.[2]

In 2005, the EU banned its use in stay-on products,[3] and in 2007 banned it in rinse-off products.[1]

In 2005–06, methyldibromoglutaronitrile/ phenoxyethanol was the ninth-most-prevalent allergen in patch tests]] (5.8%).[4]


  1. ^ a b c Ngan, Vanessa. "Allergy to methyldibromo glutaronitrile". DermNet NZ. Retrieved 21 September 2013. 
  2. ^ "Allergy to methyldibromo glutaronitrile". 2014-01-20. Retrieved 2014-04-09. 
  3. ^ Jeanne Duus Johansen; Peter J. Frosch; Jean-Pierre Lepoittevin (29 September 2010). Contact Dermatitis. Springer. p. 575. ISBN 978-3-642-03827-3. Retrieved 21 September 2013. 
  4. ^ Zug KA, Warshaw EM, Fowler JF Jr, Maibach HI, Belsito DL, Pratt MD, Sasseville D, Storrs FJ, Taylor JS, Mathias CG, Deleo VA, Rietschel RL, Marks J. Patch-test results of the North American Contact Dermatitis Group 2005–2006. Dermatitis. 2009 May–Jun;20(3):149-60.

External links[edit]