Methylglyoxal reductase (NADH-dependent)

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methylglyoxal reductase (NADH-dependent)
Identifiers
EC number1.1.1.78
CAS number37250-16-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a methylglyoxal reductase (NADH-dependent) (EC 1.1.1.78) is an enzyme that catalyzes the chemical reaction

(R)-lactaldehyde + NAD+ methylglyoxal + NADH + H+

Thus, the two substrates of this enzyme are (R)-lactaldehyde and NAD+, whereas its 3 products are methylglyoxal, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-lactaldehyde:NAD+ oxidoreductase. Other names in common use include methylglyoxal reductase, and D-lactaldehyde dehydrogenase. This enzyme participates in pyruvate metabolism.

References[edit]

  • Ting SM, Miller ON, Sellinger OZ (1965). "The Metabolism of lactaldehyde: VII. The oxidation of d-lactaldehyde in rat liver". Biochim. Biophys. Acta. 97: 407&ndash, 15. doi:10.1016/0304-4165(65)90151-0. PMID 14323585.