Miltiradiene synthase

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Miltiradiene synthase
Identifiers
EC number4.2.3.131
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Miltiradiene synthase (EC 4.2.3.131, SmMDS, SmiKSL) is an enzyme with systematic name (+)-copaly-diphosphate diphosphate-lyase (cyclizing, miltiradiene-forming).[1][2] This enzyme catalyses the following chemical reaction

(+)-copalyl diphosphate miltiradiene + diphosphate

This enzyme is isolated from the plant Selaginella moellendorffii.

References[edit]

  1. ^ Gao, W., Hillwig, M.L., Huang, L., Cui, G., Wang, X., Kong, J., Yang, B. and Peters, R.J. (2009). "A functional genomics approach to tanshinone biosynthesis provides stereochemical insights". Org. Lett. 11: 5170–5173. doi:10.1021/ol902051v. PMC 2776380. PMID 19905026.
  2. ^ Sugai, Y., Ueno, Y., Hayashi, K., Oogami, S., Toyomasu, T., Matsumoto, S., Natsume, M., Nozaki, H. and Kawaide, H. (2011). "Enzymatic 13C labeling and multidimensional NMR analysis of miltiradiene synthesized by bifunctional diterpene cyclase in Selaginella moellendorffii". J. Biol. Chem. 286: 42840–42847. doi:10.1074/jbc.m111.302703. PMC 3234827. PMID 22027823.

External links[edit]