The Ministry of Transport and Sustainable Mobility (MITMA), traditionally known as the Ministry of Development (MIFOM), is the department of the Government of Spain responsible for preparing and implementing the government policy on land, air and maritime transport infrastructure and the control, planning and regulation of the transport services on this areas. It is also responsible for guaranteeing access to housing; urban, soil and architecture policies; planning and controlling the postal and telegraph services, directing the services related to astronomy, geodesy, geophysics and mapping, and planning and programing the government investments on infrastructure and services related to this scope. The Ministry's headquarters are in the New Ministries government complex.

The Ministry of Health (MISAN) is the department of the Government of Spain responsible for proposing and executing the government policy on health, planning and providing healthcare as well as the exercise of the powers of the General State Administration to assure citizens the right to health protection. The Ministry is headquartered in the Paseo del Prado in Madrid, opposite the Prado Museum.