Minnesota State University, Mankato is a public university in Mankato, Minnesota, United States. It is Minnesota's second-largest university and has over 145,000 living alumni worldwide. Founded in 1868, it is the second-oldest member of the Minnesota State Colleges and Universities system and is commonly referred to as the flagship institution. It was established as the Second State Normal School in 1858 and officially opened as Mankato Normal School a decade later. Minnesota State University, Mankato is a significant contributor to the local and state economies, adding $827 million annually.

Mankato is a city in Blue Earth, Nicollet, and Le Sueur counties in the U.S. state of Minnesota. It is the county seat of Blue Earth County, Minnesota. The population was 44,488 according to the 2020 census, making it the 21st-largest city in Minnesota, and the 5th-largest outside of the Minneapolis–Saint Paul metropolitan area. It is along a large bend of the Minnesota River at its confluence with the Blue Earth River. Mankato is across the Minnesota River from North Mankato. Mankato and North Mankato have a combined population of 58,763 according to the 2020 census. It completely encompasses the town of Skyline. North of Mankato Regional Airport, a tiny non-contiguous part of the city lies within Le Sueur County. Most of the city is in Blue Earth County.