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Mirtazapine, sold under the brand name Remeron among others, is an antidepressant used to treat depression. Its full effect may take more than four weeks to occur, with some benefit as early as one to two weeks, it is used in depression complicated by anxiety or trouble sleeping. It is taken by mouth. Common side effects include increased weight and dizziness. Serious side effects may include mania, low white blood count, increased suicide among children. Withdrawal symptoms may occur with stopping, it is not recommended together with an MAO inhibitor. It is unclear. How it works is not clear. Chemically, it is a tetracyclic antidepressant, it has strong antihistamine effects. Mirtazapine came into medical use in the United States in 1996; the patent expired in 2004, generic versions are available. In the United States the wholesale cost as of 2018 is about US$3 per month. In the United Kingdom a month supply costs the NHS about £1.60 per month as of 2018. In 2016 it was the 128th most prescribed medication in the United States with about 5.5 million prescriptions.

Mirtazapine is used for major depressive disorder and other mood disorders. Onset of action appears similar to tricyclic antidepressants. There is some tentative evidence supporting its use in treating the following conditions, for which it is sometimes prescribed off-label: In 2010 NICE recommended generic SSRIs as first line choices, as they are "equally effective as other antidepressants and have a favourable risk–benefit ratio." With respect to mirtazapine, it found: "There is no difference between mirtazapine and other antidepressants on any efficacy measure, although in terms of achieving remission mirtazapine appears to have a statistical though not clinical advantage. In addition, mirtazapine has a statistical advantage over SSRIs in terms of reducing symptoms of depression, but the difference is not clinically important. However, there is strong evidence that patients taking mirtazapine are less to leave treatment early because of side effects, although this is not the case for patients reporting side effects or leaving treatment early for any reason."A 2011 Cochrane review that compared mirtazapine to other antidepressants found that, while it appears to have a faster onset in people for whom it works, its efficacy is about the same as other antidepressants after 6 weeks' use.

A 2012 review focused on antidepressants and sleep found that in many people with sleep disorders caused by depression, mirtazapine reduces the time it takes to fall asleep and increases the quality of sleep, but that in some people it can disturb sleep at higher doses, causing restless leg syndrome in 8 to 28% of people and in rare cases causes REM sleep behavior disorder. A 2018 analysis of 21 antidepressants found them to be similar overall, it found tentative evidence for mirtazapine being in the more effective group and middle in tolerability. After one week of usage, mirtazapine was found to have an earlier onset of action compared to SSRIs. A 2011 Cochrane review found that compared with other antidepressants, it is more to cause weight gain and sleepiness, but it is less to cause tremor than tricyclic antidepressants, less to cause nausea and sexual dysfunction than SSRIs. Common adverse effects include constipation, dry mouth, increased appetite and weight gain. Common adverse effects include weakness, dizziness, peripheral edema, negative lab results like elevated transaminases, elevated serum triglycerides, elevated total cholesterol.

Mirtazapine is not considered to have a risk of many of the side effects associated with other antidepressants like the SSRIs, may improve certain ones when taken in conjunction with them. In general, some antidepressants SSRIs, can paradoxically exacerbate some peoples' depression or anxiety or cause suicidal ideation. Despite its sedating action, mirtazapine is believed to be capable of this, so in the United States and certain other countries, it carries a black box label warning of these potential effects for people under the age of 25. A case report published in 2000 noted an instance in which mirtazapine counteracted the action of clonidine, causing a dangerous rise in blood pressure. Mirtazapine and other antidepressants may cause a discontinuation syndrome upon cessation. A gradual and slow reduction in dose is recommended to minimize discontinuation symptoms. Effects of sudden cessation of treatment with mirtazapine may include depression, tinnitus, panic attacks, restlessness, decreased appetite, diarrhea, vomiting, flu-like symptoms such as allergies and pruritus and sometimes hypomania or mania.

Mirtazapine is considered to be safe in the event of an overdose, although it is considered more toxic in overdose than most of the SSRIs. Unlike the tricyclic antidepressants, mirtazapine showed no significant cardiovascular adverse effects at 7 to 22 times the maximum recommended dose. Case reports of overdose with as much as 30 to 50 times the standard dose described the drug as nontoxic, compared to tricyclic antidepressants. Twelve reported; the fatal toxicity index (deaths per million p

100 Years Ago

"100 Years Ago" is a song by the Rolling Stones featured on their 1973 album Goats Head Soup. Credited to Mick Jagger and Keith Richards, guitarist Mick Taylor said at the time of its release, "Some of the songs we used were pretty old.'100 Years Ago' was one that Mick had written two years ago and which we hadn't got around to using before." The song is described by Tom Maginnis in his review as having a, "wistful air with a country lilt... before making several tempo shifts into a funky, sped-up groove..." The song's lyrics see Jagger reflect on aging: Now all my friends is wearing worried smiles, Living out a dream of what they was. Went out walkin' through the wood the other day. What tender days, we had no secrets hid away. Recording took place at Kingston's Dynamic Sound Studios in November and December, 1972, with a final mix conducted in June 1973. Jagger performs lead vocals and is accompanied by Taylor on backing. Taylor performs the song's guitars while Keith Richards and Charlie Watts perform bass and drums, respectively.

Nicky Hopkins provides piano while Billy Preston performs clavinet. "100 Years Ago" was only played on the first two performances of European Tour of 1973, has not been performed live since. Complete official lyrics Lyrics of this song at MetroLyrics

Izumino Station

Izumino Station is a railway station on the Sotetsu Izumino Line in Izumi-ku, Kanagawa Prefecture, operated by the private railway operator Sagami Railway. Izumino Station is served by the Sagami Railway Izumino Line, lies 6.0 km from the starting point of the line at Futamatagawa Station. The station has two island platforms serving four tracks, connected to the station building by an overpass; the station building is elevated, is built over the platforms and tracks. Platforms 1 and 4 are used by Rapid services. Izumino Station opened on April 1976 as the terminus of the Izumino Line. On April 4, 1990, the line was further extended to Izumi-chūō. In fiscal 2011, the station was used by an average of 14,055 passengers daily. Kanagawa Prefectural Shoyo High School Shuei High School Sotetsu station information

Léon Goldberg

Léon Goldberg, called "Julien", was a Polish Jew and volunteer fighter in the French Liberation army FTP-MOI in the Manouchian Group. Goldberg was born in Poland. In 1928 his father, Samuel Goldberg, immigrated to France bringing his wife Riwka Gelemer and his son in 1929, they stayed in Paris where two other children were born, Henry in 1931 and Max in 1934. When the mass arrest of more than 13,000 Jews, the Vel' d'Hiv Roundup, was carried out in Paris on 16 July 1942, Léon's parents sent him and his two brothers into hiding with a neighbour, his parents were arrested. His mother and two brothers were held at the Pithiviers and Drancy transit camps, deported to Auschwitz on 19 August 1942. Goldberg was known within the resistance under the pseudonym "Julien", his false papers were in the name of "Gérard Charton". On 23 September 1943 Goldberg, Joseph Boczov and two other fighters from the FTP-MOI took a train to Brie-Comte-Robert. From there they made their way to Coubert; the next day they took the train to Lieusaint to return to Paris.

On 21 October 1943 Goldberg, Maurice Fingercwajg, Jonas Geduldig, Thomas Elek and a sixth resistance fighter, all from the MOI, left on a mission to stop a German convoy on the Paris-Troyes line at Grandpuits near Mormant. During the night they attacked a train with 51 wagons. 27 wagons were destroyed, blocking the two rails and destroying wheat, assorted packages and aircraft engines. The guards were killed and the train driver was injured. However, the fighters had been observed by the BS2. Three of the participants were killed or taken prisoner, the other three escaped but were identified. Goldberg was arrested at Mormant, shot at the fort Mont Valérien on 21 February 1944 with the other members of the Affiche rouge. Francs-tireurs et partisans - Main-d'œuvre immigrée Affiche rouge French Resistance Brigades Spéciales Geheime Feld Polizei La journée d'un « Terroriste » Discours d'André Santini et Henry Karayan Article de Léon Goldberg Arrestation de Léon Goldberg

2012–13 Bayernliga

The 2012–13 season of the Bayernliga, the second highest association football league in Bavaria after the creation of the new Regionalliga Bayern, was the fifth season of the league at tier five of the German football league system and the 68th season overall since establishment of the league in 1945. The regular season started on 17 July 2012 and finished on 25 May 2013, followed by relegation play-off games; the league season was interrupted by a winter break, which lasted from 8 December 2012 to 22 February 2013. The league was split into a northern and a southern division, a system last in place in the 1962–63 season, expanding from 18 clubs to 37; the division featured fourteen new clubs with only TSV Großbardorf, FSV Erlangen-Bruck, Würzburger FV and FC Schweinfurt 05 having played in the Bayernliga in the previous season. The division featured fifteen new clubs with only SB/DJK Rosenheim, TSV Aindling, TSV Gersthofen and SpVgg Unterhaching II having played in the Bayernliga in the previous season.

The top goal scorers for the season: The third placed teams of each Bayernliga division, TSV Großbardorf and BC Aichach, played the 16th and 17th placed Regionalliga Bayern teams, FC Augsburg II and SpVgg Bayern Hof for two spots in the 2013–14 Regionalliga. Both Augsburg and Hof retained their league place while Aichach and Großbardorf failed to gain promotion: First leg Second leg The second placed teams of each Landesliga division, together with the 15th placed team from the Bayernliga Nord and the 15th and 16th placed team Bayernliga Süd entered a play-off for two more places in the 2013–14 Bayernliga. All three Bayernliga clubs were relegated while the Landesliga teams of SV Raisting and VfR Garching were promoted: First round – first leg First round – second leg Second round – first leg Second round – second leg Official website of the Bavarian Football Association Bayernliga Nord 2012–13 on Bayernliga Süd 2012–13 on

Indiana Collegiate Hockey Conference

The Indiana Collegiate Hockey Conference is a collegiate hockey conference within Division 3 of the American Collegiate Hockey Association. The ICHC facilitates and fosters competitive and operational excellence for its member institutions through the club sport of ice hockey; the conference supports a culture of professionalism and integrity all while creating a positive experience for the student-athletes and academic institutions it serves. The ICHC began play in the 2014-2015 season. All four teams participated in the ICHC Showcase, which were the first games in conference history, from October 10–12th, 2014; the showcase was hosted by IPFW. The first ICHC Playoffs was hosted by Purdue. Ball State University IPFW Xavier University moved to ACHA Division II </ ACHA Web site