Mount Guyot is a mountain in the Great Smoky Mountains, located in the southeastern United States. At 6,621 feet (2,018 m) in elevation, Guyot is the fourth-highest summit in the Eastern U.S., and the second-highest in the Great Smoky Mountains National Park. While the mountain is remote, the Appalachian Trail crosses its south slope, passing to within 1,000 feet (300 m) of the summit.

Great Smoky Mountains National Park is an American national park in the southeastern United States, with parts in North Carolina and Tennessee. The park straddles the ridgeline of the Great Smoky Mountains, part of the Blue Ridge Mountains, which are a division of the larger Appalachian Mountain chain. The park contains some of the highest mountains in eastern North America, including Clingmans Dome, Mount Guyot, and Mount Le Conte. The border between the two states runs northeast to southwest through the center of the park. The Appalachian Trail passes through the center of the park on its route from Georgia to Maine. With 13 million visitors in 2023, the Great Smoky Mountains National Park is the most visited national park in the United States.