Murphy is a town in and the county seat of Cherokee County, North Carolina, United States. It is situated at the confluence of the Hiwassee and Valley rivers. It is the westernmost county seat in the state of North Carolina, approximately 360 miles (580 km) from the state capital in Raleigh. The population of Murphy was 1,608 at the 2020 census.

Cherokee County is the westernmost county in the U.S. state of North Carolina. It borders Tennessee to its west and Georgia to its south. As of the 2020 census, the population was 28,774. The county seat is Murphy.