Mutacin 1140

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Mutacin 1140
Names
Systematic IUPAC name
L-Phenylalanyl-L-lysyl-D-cysteinyl-L-tryptophyl-2,3-didehydroalanyl-L-leucyl-L-cysteinyl-(2S)-2-amino-3-mercaptobutanoyl-L-prolylglycyl-L-cysteinyl-L-alanyl-L-arginyl-(2Z)-2-amino-2-butenoylglycyl-D-cysteinyl-L-phenylalanyl-L-asparaginyl-D-cysteinyl-L-tyrosyl-N-[(1Z)-2-mercaptoethenyl]-L-cysteinamide, cyclic (37),(811),(16213),(19211)-tetrakis(thioether)
Other names
MU1140
Identifiers
Properties
C103H138N28O23S4
Molar mass 2264.65 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Mutacin 1140 is a bacteriocin produced by Streptococcus mutans.[1] It has activity against a broad spectrum of Gram-positive bacteria, it is a member of the class of compounds known as lantibiotics.


Mutacin 1140 belongs to the epidermin subset of type Al lantibiotics. Molecules belonging to this family bind to lipid II which is a precursor to bacterial cell wall synthesis.[2]

While the effect Mutacin 1140 has against gram-positive bacteria are known, it remains difficult to study due to it demonstrating poor pharmacokinetics. Besides the poor pharmacokinetics, it is easily vulnerable to proteolytic degradation by interfering with the protein's peptide bonds.[2]


References[edit]

  1. ^ Smith, L; Zachariah, C; Thirumoorthy, R; Rocca, J; Novák, J; Hillman, JD; Edison, AS (2003). "Structure and dynamics of the lantibiotic mutacin 1140". Biochemistry. 42 (35): 10372–84. doi:10.1021/bi034490u. PMID 12950164.
  2. ^ a b Geng, Mengxin; Ravichandran, Akshaya; Escano, Jerome; Smith, Leif (2018-10-01). "Efficacious Analogs of the Lantibiotic Mutacin 1140 against a Systemic Methicillin-Resistant Staphylococcus aureus Infection". Antimicrobial Agents and Chemotherapy. 62 (12). doi:10.1128/aac.01626-18. ISSN 0066-4804.