N-Desalkylflurazepam

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N-Desalkylflurazepam
Desalkylflurazepam.svg
Desalkylflurazepam ball-and-stick model.png
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
Formula C15H10ClFN2O
Molar mass 288.70 g/mol
3D model (JSmol)
Melting point 205 to 206 °C (401 to 403 °F) [1]

N-Desalkylflurazepam (also known as Norflurazepam) is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam,[2] flutoprazepam,[3] fludiazepam,[4] midazolam,[5] quazepam,[6] and ethyl loflazepate.[7][8] It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes,[6] it has been sold as a designer drug from 2016 onward.[9]

Synonyms[edit]

References[edit]

  1. ^ SciFinder record for CAS#2886-65-9
  2. ^ Riva, Roberto; De Anna, Marco; Albani, Fiorenzo; Baruzzi, Agostino (1981). "Rapid quantitation of flurazepam and its major metabolite, N-desalkylflurazepam, in human plasma by gas—liquid chromatography with electron-capture detection". Journal of Chromatography B. 222 (3): 491–495. doi:10.1016/S0378-4347(00)84153-5. 
  3. ^ Barzaghi, N; Leone, L; Monteleone, M; Tomasini, G; Perucca, E (1989). "Pharmacokinetics of flutoprazepam, a novel benzodiazepine drug, in normal subjects". European journal of drug metabolism and pharmacokinetics. 14 (4): 293–8. doi:10.1007/bf03190114. PMID 2633923. 
  4. ^ J. Descotes, ed. (1996). Human Toxicology. p. 43. 
  5. ^ Vogt, Susanne; Kempf, Jürgen; Buttler, Jürgen; Auwärter, Volker; Weinmann, Wolfgang (2013). "Desalkylflurazepam found in patients' samples after high-dose midazolam treatment". Drug Testing and Analysis. 5 (9–10): 745–7. doi:10.1002/dta.1484. PMID 23713025. 
  6. ^ a b Nikaido, AM; Ellinwood Jr, EH (1987). "Comparison of the effects of quazepam and triazolam on cognitive-neuromotor performance". Psychopharmacology. 92 (4): 459–64. doi:10.1007/bf00176478. PMID 2888152. 
  7. ^ B. B. Ba, A. Iliadis, J. P. Cano; Iliadis; Cano (1989). "Pharmacokinetic modeling of ethyl loflazepate (VictanR) and its main active metabolites". Annals of Biomedical Engineering. 17 (6): 633–646. doi:10.1007/bf02367467. PMID 2574017. 
  8. ^ Davi, H.; Guyonnet, J.; Necciari, J.; Cautreels, W. (1985). "Determination of circulating ethyl loflazepate metabolites in the baboon by radio-high-performance liquid chromatography with injection of crude plasma samples: Comparison with solvent extraction and thin-layer chromatography". Journal of Chromatography B. 342: 159–165. doi:10.1016/S0378-4347(00)84498-9. 
  9. ^ Manchester, Kieran R.; Maskell, Peter D.; Waters, Laura (2018). "Experimental versus theoretical log D7.4, pKa and plasma protein binding values for benzodiazepines appearing as new psychoactive substances". Drug Testing and Analysis. doi:10.1002/dta.2387. ISSN 1942-7611. PMID 29582576.