N-acetylmuramic acid 6-phosphate etherase

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N-acetylmuramic acid 6-phosphate etherase
EC number
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ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

N-acetylmuramic acid 6-phosphate etherase (EC, MurNAc-6-P etherase, MurQ) is an enzyme with systematic name (R)-lactate hydro-lyase (adding N-acetyl-D-glucosamine 6-phosphate; N-acetylmuramate 6-phosphate-forming).[1][2][3][4][5] This enzyme catalyses the following chemical reaction

(R)-lactate + N-acetyl-D-glucosamine 6-phosphate N-acetylmuramate 6-phosphate + H2O

This enzyme is required for the utilization of anhydro-N-acetylmuramic acid in proteobacteria.


  1. ^ Jaeger, T.; Arsic, M.; Mayer, C. (2005). "Scission of the lactyl ether bond of N-acetylmuramic acid by Escherichia coli "etherase"". J. Biol. Chem. 280: 30100–30106. doi:10.1074/jbc.m502208200. PMID 15983044. 
  2. ^ Uehara, T.; Suefuji, K.; Valbuena, N.; Meehan, B.; Donegan, M.; Park, J.T. (2005). "Recycling of the anhydro-N-acetylmuramic acid derived from cell wall murein involves a two-step conversion to N-acetylglucosamine-phosphate". J. Bacteriol. 187: 3643–3649. doi:10.1128/jb.187.11.3643-3649.2005. PMC 1112033Freely accessible. PMID 15901686. 
  3. ^ Uehara, T.; Suefuji, K.; Jaeger, T.; Mayer, C.; Park, J.T. (2006). "MurQ etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall". J. Bacteriol. 188: 1660–1662. doi:10.1128/jb.188.4.1660-1662.2006. PMC 1367226Freely accessible. PMID 16452451. 
  4. ^ Hadi, T.; Dahl, U.; Mayer, C.; Tanner, M.E. (2008). "Mechanistic studies on N-acetylmuramic acid 6-phosphate hydrolase (MurQ): an etherase involved in peptidoglycan recycling". Biochemistry. 47: 11547–11558. doi:10.1021/bi8014532. PMID 18837509. 
  5. ^ Jaeger, T.; Mayer, C. (2008). "N-acetylmuramic acid 6-phosphate lyases (MurNAc etherases): role in cell wall metabolism, distribution, structure, and mechanism". Cell. Mol. Life Sci. 65: 928–939. doi:10.1007/s00018-007-7399-x. PMID 18049859. 

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