NEFA (drug)

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PubChem CID
Chemical and physical data
Formula C15H19N
Molar mass 213.3181 g/mol
3D model (JSmol)

NEFA is a moderate affinity NMDA antagonist (IC50 = 0.51 μM). It is a structural analog of phencyclidine.[1] It was first synthesized by a team at Parke-Davis in the late 1950s.[2]


  1. ^ Dilmore JG, Johnson JW (1998). "Open channel block and alteration of N-methyl-D-aspartic acid receptor gating by an analog of phencyclidine". Biophysical Journal. 75 (4): 1801–16. doi:10.1016/S0006-3495(98)77622-2. PMC 1299852Freely accessible. PMID 9746522. 
  2. ^ GB Patent 893920 - Polycyclic amino compounds and methods for their production