NXT TakeOver: Philadelphia was the 18th NXT TakeOver professional wrestling livestreaming event produced by WWE. It was held exclusively for wrestlers from the promotion's NXT brand division. The event aired exclusively on the WWE Network and took place on January 27, 2018, at the Wells Fargo Center in Philadelphia, Pennsylvania as part of that year's Royal Rumble weekend.

The Wells Fargo Center is a multi-purpose indoor arena located in Philadelphia. It serves as the home of the Philadelphia Flyers of the National Hockey League (NHL), the Philadelphia 76ers of the National Basketball Association (NBA), and the Philadelphia Wings of the National Lacrosse League (NLL). The arena lies at the southwest corner of the South Philadelphia Sports Complex, which includes Lincoln Financial Field, Citizens Bank Park, and Xfinity Live!.