The Mitre Corporation is an American not-for-profit organization based in Bedford, McLean, Virginia. It manages federally funded research and development centers supporting several U. S. government agencies. Mitre is organized as follows: Additionally, internal research and development explores new technologies and ways to apply existing tools and technologies. Among other efforts, Mitre maintains the Common Vulnerabilities and Exposures system and the Common Weakness Enumeration project. Since 1999, the Mitre Corporation functions as editor and primary CNA of the Common Vulnerabilities and Exposures). CVE is now the industry standard for vulnerability and exposure names, providing reference points for data exchange so that information security products and services can interoperate with each other. Under the leadership of C. W. Halligan, Mitre was formed in 1958 to provide overall direction to the companies and workers involved in the U. S. Air Force SAGE project. Most of the early employees were transferred to Mitre from the Lincoln Laboratory at the Massachusetts Institute of Technology, where SAGE was being developed.
In April 1959, a site was purchased in Bedford, near Hanscom Air Force Base, to develop a new Mitre laboratory, which Mitre occupied in September 1959. After the SAGE project ended in the early 1960s, the FAA selected Mitre to develop a similar system to provide automated air traffic control; the result of the project formed the National Airspace System, still in use today. To support the NAS project and continual operations with the U. S. Department of Defense at the Pentagon, Mitre opened a second "main office" in Virginia. Through the 1960s, Mitre developed and supported military Command, Control and Intelligence projects, including the Airborne Warning and Control System. Mitre worked on a number of projects with ARPA, including precursors to the Advanced Research Projects Agency Network. Since the 1960s, Mitre has developed or supported most DoD early warning and communications projects, including the Joint Tactical Information Distribution System and the Joint Surveillance and Target Attack Radar System.
In 1982, the Mitre Corporation authored a proposal for the State Department called "Cannabis Eradication in Foreign Western Nations." In this proposal, a plan was outlined to eradicate cannabis in participating nations within 121 days, for $19 million. The report discussed the safety considerations of paraquat; the plan would have been to aerially dispense paraquat over marijuana crops. One safety concern was the food crops grown alongside the marijuana crops being contaminated. A study conducted on rats by Imperial Chemical Industries was cited in the report, claimed low health risks for paraquat; the U. S. Public Health Service commented on this study saying that due to the present squamous metaplasia in the respiratory tracts of the rats that "This study should not be used to calculate the safe inhalation dose of paraquat in humans."During the 1980s, the German hacker Markus Hess used an unsecured Mitre Tymnet connection as an entry point for intrusions into U. S. Department of Defense, Department of Energy, NASA computer networks.
On July 10, 1985, mitre.org was the first.org domain name registered, it remains in use by the company today. On January 29, 1996, Mitre divided into two entities: The Mitre Corporation, to focus on its FFRDCs for DoD and FAA. S. Government agencies. In 2005, a team from Mitre competed in the 2005 DARPA Grand Challenge, qualified in 23rd place for the final race. 1958–1966: C. W. Halligan 1966–1969: Dr. John L. McLucas 1969–1986: Robert R. Everett 1986–1990: Charles A. Zraket 1990–1996: Barry M. Horowitz 1996–2000: Victor A. DeMarines 2000–2006: Martin C. Faga 2006–2017: Alfred Grasso 2017–Present: Jason Providakes Over the years, Mitre has received awards for corporate achievements as well as for achievements of its scientists and engineers. A sampling includes: In 2015, Forbes Magazine named Mitre one of America's Best Employers. In 2013, Mitre was named a 2013 CSO40 Award winner by the International Data Group's CSO Magazine; the CSO40 Awards recognize 40 organizations for security projects and initiatives that demonstrate outstanding business value and thought leadership.
In 2011 and 2012, InformationWeek named Mitre to its InformationWeek 500, an annual ranking of the nation's most innovative users of business technology. In 2011, for the second time, Mitre's knowledge management successes have earned the corporation a North American Most Admired Knowledge Enterprises award, which recognizes organizations for exceptional knowledge management and knowledge sharing practices. In June 2008, Mitre was presented with the Secretary of Defense Medal for Outstanding Public Service for "significant contributions in communications and control decision-making, intelligence and warfighter field support, as well as research and development." In July 2008, Mitre was awarded the Air Force Association's Theodore Von Karman award for "the most outstanding contribution in the field of engineering and science." In July 2008, Mitre's Center for Advanced Aviation System Development, as part of an ADS-B team of 26 public and private sector groups, was selected for the 2007 Collier Trophy for its efforts in conceptualizing and implementing a fundamental, so-called "cornerstone capability" for the future of the national airspace system.
Mitre has been included on annual lists of several magazines: Glassdoor.com has named Mitre one of the “50 Best Places to Work” for five consecutive years
Johns Hopkins University
Johns Hopkins University is a private research university in Baltimore, Maryland. Founded in 1876, the university was named for its first benefactor, the American entrepreneur and philanthropist Johns Hopkins, his $7 million bequest —of which half financed the establishment of Johns Hopkins Hospital—was the largest philanthropic gift in the history of the United States up to that time. Daniel Coit Gilman, inaugurated as the institution's first president on February 22, 1876, led the university to revolutionize higher education in the U. S. by integrating teaching and research. Adopting the concept of a graduate school from Germany's ancient Heidelberg University, Johns Hopkins University is considered the first research university in the United States. Over the course of several decades, the university has led all U. S. universities in annual research and development expenditures. In fiscal year 2016, Johns Hopkins spent nearly $2.5 billion on research. Johns Hopkins is organized into 10 divisions on campuses in Maryland and Washington, D.
C. with international centers in Italy and Singapore. The two undergraduate divisions, the Zanvyl Krieger School of Arts and Sciences and the Whiting School of Engineering, are located on the Homewood campus in Baltimore's Charles Village neighborhood; the medical school, the nursing school, the Bloomberg School of Public Health are located on the Medical Institutions campus in East Baltimore. The university consists of the Peabody Institute, the Applied Physics Laboratory, the Paul H. Nitze School of Advanced International Studies, the School of Education, the Carey Business School, various other facilities. Johns Hopkins was a founding member of the American Association of Universities. Johns Hopkins University is cited as among the world's top universities; the university is ranked 10th among undergraduate programs at National Universities in U. S. News & World Report latest rankings, 10th among global universities by U. S. News & World Report in its 2019 rankings, as well as 12th globally in the Times Higher Education World University Rankings.
Over the course of more than 140 years, 37 Nobel laureates and 1 Fields Medalist have been affiliated with Johns Hopkins. Founded in 1883, the Blue Jays men's lacrosse team has captured 44 national titles and joined the Big Ten Conference as an affiliate member in 2014. On his death in 1873, Johns Hopkins, a Quaker entrepreneur and childless bachelor, bequeathed $7 million to fund a hospital and university in Baltimore, Maryland. At that time this fortune, generated from the Baltimore and Ohio Railroad, was the largest philanthropic gift in the history of the United States; the first name of philanthropist Johns Hopkins is the surname of his great-grandmother, Margaret Johns, who married Gerard Hopkins. They named their son Johns Hopkins. Samuel named one of his sons for his father and that son would become the university's benefactor. Milton Eisenhower, a former university president, once spoke at a convention in Pittsburgh where the Master of Ceremonies introduced him as "President of John Hopkins."
Eisenhower retorted that he was "glad to be here in Pittburgh." The original board opted for an novel university model dedicated to the discovery of knowledge at an advanced level, extending that of contemporary Germany. Building on the Humboldtian model of higher education, the German education model of Wilhelm von Humboldt, it became dedicated to research. Johns Hopkins thereby became the model of the modern research university in the United States, its success shifted higher education in the United States from a focus on teaching revealed and/or applied knowledge to the scientific discovery of new knowledge. The trustees worked alongside four notable university presidents – Charles W. Eliot of Harvard, Andrew D. White of Cornell, Noah Porter of Yale College and James B. Angell of Michigan, they each vouched for Daniel Coit Gilman to lead the new University and he became the university's first president. Gilman, a Yale-educated scholar, had been serving as president of the University of California prior to this appointment.
In preparation for the university's founding, Gilman visited University of Freiburg and other German universities. Gilman launched what many at the time considered an audacious and unprecedented academic experiment to merge teaching and research, he dismissed the idea that the two were mutually exclusive: "The best teachers are those who are free and willing to make original researches in the library and the laboratory," he stated. To implement his plan, Gilman recruited internationally known luminaries such as the mathematician James Joseph Sylvester. Gilman focused on the expansion of graduate support of faculty research; the new university fused advanced scholarship with such professional schools as medicine and engineering. Hopkins became the national trendsetter in doctoral programs and the host for numerous scholarly journals and associations; the Johns Hopkins University Press, founded in 1878, is the oldest American university press in continuous operation. With the completion of Johns Hopkins Hospital in 1889 and the medical school in 1893, the university's research-focused mode of instruction soon began attracting world-renowned faculty members who would become major figures in the emerging field of acad
Pathology is the study of the causes and effects of disease or injury. The word pathology refers to the study of disease in general, incorporating a wide range of bioscience research fields and medical practices. However, when used in the context of modern medical treatment, the term is used in a more narrow fashion to refer to processes and tests which fall within the contemporary medical field of "general pathology," an area which includes a number of distinct but inter-related medical specialties that diagnose disease through analysis of tissue and body fluid samples. Idiomatically, "a pathology" may refer to the predicted or actual progression of particular diseases, the affix path is sometimes used to indicate a state of disease in cases of both physical ailment and psychological conditions. A physician practicing pathology is called a pathologist; as a field of general inquiry and research, pathology addresses four components of disease: cause, mechanisms of development, structural alterations of cells, the consequences of changes.
In common medical practice, general pathology is concerned with analyzing known clinical abnormalities that are markers or precursors for both infectious and non-infectious disease and is conducted by experts in one of two major specialties, anatomical pathology and clinical pathology. Further divisions in specialty exist on the basis of the involved sample types and physiological systems, as well as on the basis of the focus of the examination. Pathology is a significant field in medical research; the study of pathology, including the detailed examination of the body, including dissection and inquiry into specific maladies, dates back to antiquity. Rudimentary understanding of many conditions was present in most early societies and is attested to in the records of the earliest historical societies, including those of the Middle East and China. By the Hellenic period of ancient Greece, a concerted causal study of disease was underway, with many notable early physicians having developed methods of diagnosis and prognosis for a number of diseases.
The medical practices of the Romans and those of the Byzantines continued from these Greek roots, but, as with many areas of scientific inquiry, growth in understanding of medicine stagnated some after the Classical Era, but continued to develop throughout numerous cultures. Notably, many advances were made in the medieval era of Islam, during which numerous texts of complex pathologies were developed based on the Greek tradition. So, growth in complex understanding of disease languished until knowledge and experimentation again began to proliferate in the Renaissance and Baroque eras, following the resurgence of the empirical method at new centers of scholarship. By the 17th century, the study of microscopy was underway and examination of tissues had led British Royal Society member Robert Hooke to coin the word "cell", setting the stage for germ theory. Modern pathology began to develop as a distinct field of inquiry during the 19th Century through natural philosophers and physicians that studied disease and the informal study of what they termed “pathological anatomy” or “morbid anatomy”.
However, pathology as a formal area of specialty was not developed until the late 19th and early 20th centuries, with the advent of detailed study of microbiology. In the 19th century, physicians had begun to understand that disease-causing pathogens, or "germs" existed and were capable of reproduction and multiplication, replacing earlier beliefs in humors or spiritual agents, that had dominated for much of the previous 1,500 years in European medicine. With the new understanding of causative agents, physicians began to compare the characteristics of one germ’s symptoms as they developed within an affected individual to another germ’s characteristics and symptoms; this realization led to the foundational understanding that diseases are able to replicate themselves, that they can have many profound and varied effects on the human host. To determine causes of diseases, medical experts used the most common and accepted assumptions or symptoms of their times, a general principal of approach that persists into modern medicine.
Modern medicine was advanced by further developments of the microscope to analyze tissues, to which Rudolf Virchow gave a significant contribution, leading to a slew of research developments. By the late 1920s to early 1930s pathology was deemed a medical specialty. Combined with developments in the understanding of general physiology, by the beginning of the 20th century, the study of pathology had begun to split into a number of rarefied fields and resulting in the development of large number of modern specialties within pathology and related disciplines of diagnostic medicine; the term pathology comes from the Ancient Greek roots of pathos, meaning "experience" or "suffering" and -logia, "study of". The modern practice of pathology is divided into a number of subdisciplines within the discrete but interconnected aims of biological research and medical practice. Biomedical research into disease incorporates the
Washington State University
Washington State University is a public research university in Pullman, Washington. Founded in 1890, WSU is a land-grant university with programs in a broad range of academic disciplines. With an undergraduate enrollment of 24,470 and a total enrollment of 29,686, it is the second largest institution of higher education in Washington state behind the University of Washington; the university operates campuses across Washington known as WSU Spokane, WSU Tri-Cities, WSU Vancouver, all founded in 1989. In 2012, WSU launched an Internet-based Global Campus, which includes its online degree program, WSU Online. In 2015, WSU expanded to a sixth campus, known as WSU Everett; these campuses award bachelor's and master's degrees. Freshmen and sophomores were first admitted to the Vancouver campus in 2006 and to the Tri-Cities campus in 2007. Enrollment for the four campuses and WSU Online exceeds 29,686 students; this includes 1,751 international students. WSU's athletic teams are called the Cougars and the school colors are crimson and gray.
Six men's and nine women's varsity teams compete in NCAA Division I in the Pac-12 Conference. Both men's and women's indoor track teams compete in the Mountain Pacific Sports Federation. Washington State College was established by the Washington Legislature on March 28, 1890, less than five months after statehood; the institution was one of the land-grant colleges created under the 1862 federal Morrill Act signed into law by President Abraham Lincoln. The federal land grants for the new institution included 90,000 acres of federal land for an agricultural college and 100,000 acres for a school of science. After an extended search for a location, the state's new land-grant college opened in Pullman on January 13, 1892; the year 1897 saw the first graduating class of women. The school changed its name from Washington Agricultural College and School of Science to State College of Washington in 1905, but was called Washington State College; the state legislature changed the name to Washington State University in 1959.
Enoch Albert Bryan, appointed July 22, 1893, was the first influential president of WSU. Bryan held graduate degrees from Harvard and Columbia and served as the president of Vincennes University in Indiana. Before Bryan's arrival, the fledgling university suffered through significant organizational instability. Bryan guided WSU toward respectability and is arguably the most influential figure in the university's history; the landmark clock tower in the center of campus is his namesake. WSU's role as a statewide institution became clear in 1894 with the launch of its first agricultural experiment station west of the Cascade Mountains near Puyallup. WSU has subsequently established extension offices and research centers in all regions of the state, with major research facilities in Prosser, Mount Vernon, Wenatchee. In 1989, WSU gained branch campuses in Spokane, the Tri-Cities, Vancouver. Overall, the federal government and the State of Washington have entrusted 190,000 acres of land to WSU for agricultural and scientific research throughout the Pacific Northwest.
Professional education began with the establishment of the School of Veterinary Science in 1899. The veterinary school was elevated to college status in 1916 and became the College of Veterinary Medicine in 1925. Graduate education began in the early years and, in 1902, the first master's degree was conferred, an M. S. in Botany. In 1917, the institution was organized into five colleges and four schools, with deans as administrative heads. In 1922 a graduate school was created. In 1929, the first Ph. D. degree was conferred, in bacteriology. The university offers bachelor's, master's and doctoral degrees in 200 fields of study through 65 departments and programs; these departments and programs are organized into 10 academic colleges as follows: College of Agricultural and Natural Resource Sciences College of Arts and Sciences Carson College of Business Edward R. Murrow College of Communication College of Education Voiland College of Engineering and Architecture Elson S. Floyd College of Medicine College of Nursing College of Pharmacy College of Veterinary MedicineIn addition, WSU has an all-university honors college, a graduate school, an online global campus, an accredited intensive English program for non-native speakers.
Washington State University is chartered by the State of Washington. A board of regents provides direction to the president. There are ten regents appointed by the governor; the tenth is a student regent appointed on an annual basis. A bill adding an eleventh regent, who would be a full-time or emeritus faculty member, stalled in the Washington legislature in 2018; the regents are Theodor P. Baseler, Brett Blankenship, Scott E. Carson, Marty Dickinson, Ron Sims, Jordan Frost, Lura J. Powell, Heather Redman, Lisa K. Schauer, Michael C. Worthy. Kirk Schulz serves as WSU's president and chief executive officer. Daniel Bernardo serves as provost and handles academics and faculty matters for WSU statewide; the former president, Elson Floyd the former president of University of Missouri System, succeeded V. Lane Rawlins on May 21, 2007, served until his death on June 20, 2015. Bernardo was dean of the WSU College of Agricultural and Natural Resource Sciences. WSU has had 11 presidents in its 125-year history: George W. Lilley, John W. Heston, Enoch A. Bryan, Ernest O. Holland, Wil
University of Pennsylvania
The University of Pennsylvania is a private Ivy League research university located in the University City neighborhood of Philadelphia, Pennsylvania. It is one of the nine colonial colleges founded prior to the Declaration of Independence and the first institution of higher learning in the United States to refer to itself as a university. Benjamin Franklin, Penn's founder and first president, advocated an educational program that trained leaders in commerce and public service, similar to a modern liberal arts curriculum; the university's coat of arms features a dolphin on its red chief, adopted from Benjamin Franklin's own coat of arms. University of Pennsylvania is home many professional and graduate schools including, the first school of medicine in North America, the first collegiate business school and the first "student union" building and organization were founded at Penn; the university has four undergraduate schools which provide a combined 99 undergraduate majors in the humanities, natural sciences and engineering, as well twelve graduate and professional schools.
It provides the option to pursue specialized dual degree programs. Undergraduate admissions is competitive, with an acceptance rate of 7.44% for the class of 2023, the school is ranked as the 8th best university in the United States by the U. S. News & World Report. In athletics, the Quakers field varsity teams in 33 sports as a member of the NCAA Division I Ivy League conference and hold a total of 210 Ivy League championships as of 2017. In 2018, the university had an endowment of $13.8 billion, the seventh largest endowment of all colleges in the United States, as well as an academic research budget of $966 million. As of 2018, distinguished alumni include 14 heads of 64 billionaire alumni. S. House of Representatives. Other notable alumni include 27 Rhodes Scholars, 15 Marshall Scholarship recipients, 16 Pulitzer Prize winners, 48 Fulbright Scholars. In addition, some 35 Nobel laureates, 169 Guggenheim Fellows, 80 members of the American Academy of Arts and Sciences, many Fortune 500 CEOs have been affiliated with the university.
University of Pennsylvania considers itself the fourth-oldest institution of higher education in the United States, though this is contested by Princeton and Columbia Universities. The university considers itself as the first university in the United States with both undergraduate and graduate studies. In 1740, a group of Philadelphians joined together to erect a great preaching hall for the traveling evangelist George Whitefield, who toured the American colonies delivering open air sermons; the building was designed and built by Edmund Woolley and was the largest building in the city at the time, drawing thousands of people the first time it was preached in. It was planned to serve as a charity school as well, but a lack of funds forced plans for the chapel and school to be suspended. According to Franklin's autobiography, it was in 1743 when he first had the idea to establish an academy, "thinking the Rev. Richard Peters a fit person to superintend such an institution". However, Peters declined a casual inquiry from Franklin and nothing further was done for another six years.
In the fall of 1749, now more eager to create a school to educate future generations, Benjamin Franklin circulated a pamphlet titled "Proposals Relating to the Education of Youth in Pensilvania", his vision for what he called a "Public Academy of Philadelphia". Unlike the other Colonial colleges that existed in 1749—Harvard, William & Mary and Princeton—Franklin's new school would not focus on education for the clergy, he advocated an innovative concept of higher education, one which would teach both the ornamental knowledge of the arts and the practical skills necessary for making a living and doing public service. The proposed program of study could have become the nation's first modern liberal arts curriculum, although it was never implemented because William Smith, an Anglican priest who became the first provost and other trustees preferred the traditional curriculum. Franklin assembled a board of trustees from among the leading citizens of Philadelphia, the first such non-sectarian board in America.
At the first meeting of the 24 members of the Board of Trustees, the issue of where to locate the school was a prime concern. Although a lot across Sixth Street from the old Pennsylvania State House, was offered without cost by James Logan, its owner, the Trustees realized that the building erected in 1740, still vacant, would be an better site; the original sponsors of the dormant building still owed considerable construction debts and asked Franklin's group to assume their debts and, their inactive trusts. On February 1, 1750, the new board took over the building and trusts of the old board. On August 13, 1751, the "Academy of Philadelphia", using the great hall at 4th and Arch Streets, took in its first secondary students. A charity school was chartered July 13, 1753 in accordance with the intentions of the original "New Building" donors, although it lasted only a few years. On June 16, 1755, the "College of Philadelphia" was chartered, paving the way for the addition of undergraduate instruction.
All three schools shared the same Board of Trustees and were consider
Human blood group systems
The term human blood group systems is defined by International Society of Blood Transfusion as systems in the human species where cell-surface antigens—in particular, those on blood cells—are "controlled at a single gene locus or by two or more closely linked homologous genes with little or no observable recombination between them", include the common ABO and Rh antigen systems, as well as many others. In addition to the ABO and Rh systems, the antigens expressed on blood cell membrane surfaces include 346 red blood cell antigens and 33 platelet antigens, as defined serologically; the genetic basis for most of these antigens lie in 6 platelet genes. An individual, for example, can be AB RhD positive, at the same time M and N positive in the MNS system, K positive in the Kell system, Lea or Leb positive in the Lewis system, where these and many of the systems are named for patients in whom the corresponding antibodies were first detected. Blood is composed of cells suspended in a liquid called plasma.
Suspended in the plasma are three types of cells: Red blood cells carry oxygen White blood cells fight infection Platelets stop bleeding in injuries The most common type of grouping is the ABO blood group system. The varieties of glycoprotein and glycolipid coating on red blood cells divides blood into four groups: A B AB O Another antigen, the Rh factor, plays an important part in the grouping of blood. If this is present, the particular blood type is called Rh-positive. If it is absent, it is called Rh-negative. In addition to the ABO and Rh blood group systems, there are more than two hundred minor blood groups that can complicate blood transfusions; these are known as rare blood types. Whereas common blood types are expressed in a letter or two, which may be a plus or a minus, a smaller number of people express their blood type in an extensive series of letters in addition to their AB± type designation. For example, the h/h blood group known as Oh or the Bombay blood group, is a rare blood type.
Dean, Laura. Blood Groups and Red Cell Antigens. Bethesda, MD, USA: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health. Retrieved 19 February 2016. SIB-EBI-PIR. "Blood group Antigen Proteins: List of Entries, 17 February version". Swiss-Prot Protein Knowledgebase. Geneva, CHE: Swiss Institute of Bioinformatic, in cooperation with the European Bioinformatics Institute, the Protein Information Resource. Retrieved 19 February 2016. ISBT Table of blood group antigens within systems, updated August 2008. BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH