1.
International Standard Book Number
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The International Standard Book Number is a unique numeric commercial book identifier. An ISBN is assigned to each edition and variation of a book, for example, an e-book, a paperback and a hardcover edition of the same book would each have a different ISBN. The ISBN is 13 digits long if assigned on or after 1 January 2007, the method of assigning an ISBN is nation-based and varies from country to country, often depending on how large the publishing industry is within a country. The initial ISBN configuration of recognition was generated in 1967 based upon the 9-digit Standard Book Numbering created in 1966, the 10-digit ISBN format was developed by the International Organization for Standardization and was published in 1970 as international standard ISO2108. Occasionally, a book may appear without a printed ISBN if it is printed privately or the author does not follow the usual ISBN procedure, however, this can be rectified later. Another identifier, the International Standard Serial Number, identifies periodical publications such as magazines, the ISBN configuration of recognition was generated in 1967 in the United Kingdom by David Whitaker and in 1968 in the US by Emery Koltay. The 10-digit ISBN format was developed by the International Organization for Standardization and was published in 1970 as international standard ISO2108, the United Kingdom continued to use the 9-digit SBN code until 1974. The ISO on-line facility only refers back to 1978, an SBN may be converted to an ISBN by prefixing the digit 0. For example, the edition of Mr. J. G. Reeder Returns, published by Hodder in 1965, has SBN340013818 -340 indicating the publisher,01381 their serial number. This can be converted to ISBN 0-340-01381-8, the check digit does not need to be re-calculated, since 1 January 2007, ISBNs have contained 13 digits, a format that is compatible with Bookland European Article Number EAN-13s. An ISBN is assigned to each edition and variation of a book, for example, an ebook, a paperback, and a hardcover edition of the same book would each have a different ISBN. The ISBN is 13 digits long if assigned on or after 1 January 2007, a 13-digit ISBN can be separated into its parts, and when this is done it is customary to separate the parts with hyphens or spaces. Separating the parts of a 10-digit ISBN is also done with either hyphens or spaces, figuring out how to correctly separate a given ISBN number is complicated, because most of the parts do not use a fixed number of digits. ISBN issuance is country-specific, in that ISBNs are issued by the ISBN registration agency that is responsible for country or territory regardless of the publication language. Some ISBN registration agencies are based in national libraries or within ministries of culture, in other cases, the ISBN registration service is provided by organisations such as bibliographic data providers that are not government funded. In Canada, ISBNs are issued at no cost with the purpose of encouraging Canadian culture. In the United Kingdom, United States, and some countries, where the service is provided by non-government-funded organisations. Australia, ISBNs are issued by the library services agency Thorpe-Bowker
2.
PubMed Identifier
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PubMed is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine at the National Institutes of Health maintains the database as part of the Entrez system of information retrieval, from 1971 to 1997, MEDLINE online access to the MEDLARS Online computerized database primarily had been through institutional facilities, such as university libraries. PubMed, first released in January 1996, ushered in the era of private, free, home-, the PubMed system was offered free to the public in June 1997, when MEDLINE searches via the Web were demonstrated, in a ceremony, by Vice President Al Gore. Information about the journals indexed in MEDLINE, and available through PubMed, is found in the NLM Catalog. As of 5 January 2017, PubMed has more than 26.8 million records going back to 1966, selectively to the year 1865, and very selectively to 1809, about 500,000 new records are added each year. As of the date,13.1 million of PubMeds records are listed with their abstracts. In 2016, NLM changed the system so that publishers will be able to directly correct typos. Simple searches on PubMed can be carried out by entering key aspects of a subject into PubMeds search window, when a journal article is indexed, numerous article parameters are extracted and stored as structured information. Such parameters are, Article Type, Secondary identifiers, Language, publication type parameter enables many special features. As these clinical girish can generate small sets of robust studies with considerable precision, since July 2005, the MEDLINE article indexing process extracts important identifiers from the article abstract and puts those in a field called Secondary Identifier. The secondary identifier field is to store numbers to various databases of molecular sequence data, gene expression or chemical compounds. For clinical trials, PubMed extracts trial IDs for the two largest trial registries, ClinicalTrials. gov and the International Standard Randomized Controlled Trial Number Register, a reference which is judged particularly relevant can be marked and related articles can be identified. If relevant, several studies can be selected and related articles to all of them can be generated using the Find related data option, the related articles are then listed in order of relatedness. To create these lists of related articles, PubMed compares words from the title and abstract of each citation, as well as the MeSH headings assigned, using a powerful word-weighted algorithm. The related articles function has been judged to be so precise that some researchers suggest it can be used instead of a full search, a strong feature of PubMed is its ability to automatically link to MeSH terms and subheadings. Examples would be, bad breath links to halitosis, heart attack to myocardial infarction, where appropriate, these MeSH terms are automatically expanded, that is, include more specific terms. Terms like nursing are automatically linked to Nursing or Nursing and this important feature makes PubMed searches automatically more sensitive and avoids false-negative hits by compensating for the diversity of medical terminology. The My NCBI area can be accessed from any computer with web-access, an earlier version of My NCBI was called PubMed Cubby
3.
Proteobacteria
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The Proteobacteria are a major phylum of Gram-negative bacteria. The name of the phylum has never been published as no type genus has been proposed. They include a variety of pathogens, such as Escherichia, Salmonella, Vibrio, Helicobacter, Yersinia. Others are free-living, and include many of the responsible for nitrogen fixation. Carl Woese established this grouping in 1987, calling it informally the purple bacteria, the Alphaproteobacteria grow at very low levels of nutrients and have unusual morphology such as stalks and buds. They include agriculturally important bacteria capable of inducing nitrogen fixation in symbiosis with plants, the type order is the Caulobacterales, comprising stalk-forming bacteria such as Caulobacter. The Betaproteobacteria are highly diverse and contain chemolithoautotrophs, photoautotrophs. The type order is the Burkholderiales, comprising a range of metabolic diversity. The Gammaproteobacteria are the largest class in terms of species with validly published names, the type order is the Pseudomonadales, which include the genera Pseudomonas and the nitrogen-fixing Azotobacter. The Deltaproteobacteria include bacteria that are predators on other bacteria and are important contributors to the side of the sulfur cycle. The type order is the Myxococcales, which includes organisms with self-organising abilities such as Myxococcus spp, the Epsilonproteobacteria are often slender, Gram-negative rods that are helical or curved. The type order is the Campylobacterales, which includes important food pathogens such as Campylobacter spp, the type order is the Oligoflexales, which contains the genus Oligoflexus. The Acidithiobacillia contain only sulfur-oxidising autotrophs, the type order is the Acidithiobacillales, which includes economically important organisms used in the mining industry such as Acidithiobacillus spp. All Proteobacteria are Gram-negative, though some may stain Gram-positive or Gram-variable in practice, many move about using flagella, but some are nonmotile or rely on bacterial gliding. The last include the Myxobacteriales, an order of bacteria that can aggregate to form fruiting bodies. Also, a variety in the types of metabolism exists. Most members are facultatively or obligately anaerobic, Chemolithoautotrophic, and heterotrophic, a variety of genera, which are not closely related to each other, convert energy from light through photosynthesis. Proteobacteria are associated with the imbalance of microbiota of the reproductive tract of women
4.
Alphaproteobacteria
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Alphaproteobacteria is a class of bacteria in the phylum Proteobacteria. Its members are diverse and possess few commonalities, but nevertheless share a common ancestor. Like all Proteobacteria, its members are Gram-negative and some of its intracellular parasitic members lack peptidoglycan and are consequently gram variable. Moreover, the class includes the protomitochondrion, the bacterium that was engulfed by the ancestor and gave rise to the mitochondria. A species of technological interest is Rhizobium radiobacter, scientists use this species to transfer foreign DNA into plant genomes. There is some disagreement on the phylogeny of the orders, especially for the location of the Pelagibacterales and this issue stems form the large difference in gene content and the large difference in GC-richness between members of several order. Specifically, Pelagibacterales, Rickettsiales and Holosporales contains species with AT-rich genomes and it has been argued that it could be a case of convergent evolution that would result in an artefactual clustering. The basal group is Magnetococcidae, which is composed by a diversity of magnetotactic bacteria. The Rickettsidae is composed of the intracellular Rickettsiales and the free-living Pelagibacterales, the Caulobacteridae is composed of the Holosporales, Rhodospirillales, Sphingomonadales, Rhodobacterales, Caulobacterales, Kiloniellales, Kordiimonadales, Parvularculales and Sneathiellales. These molecular signatures provide novel means for the circumscription of these taxonomic groups, alphaproteobacteria at the US National Library of Medicine Medical Subject Headings Bacterial Phylogeny Webpage, Alpha Proteobacteria
5.
Rickettsiales
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The Rickettsiales, also called rickettsias, are an order of small proteobacteria. Most of those described survive only as endosymbionts of other cells, some are notable pathogens, including Rickettsia, which causes a variety of diseases in humans. On the other end of the scale, genetic studies support the theory according to which mitochondria. Some have also speculated that viruses might have developed from them, the Rickettsiales are among the most mysterious groups of Proteobacteria, owing largely to difficulties in cultivating them. The group includes all obligate endosymbiont bacteria, however, a number of species have been removed, such as Coxiella burnetii, the cause of Q fever. The Rickettsiales has an order the Pelagibacterales, which is composed of free living bacteria with extremely streamlined genomes. The relation between the two order is retained in the subclass, the Rickettsidae, which include the Rickettsiales, the Pelagibacteriales and the extinct protomitochondrion
6.
Rickettsia rickettsii
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Rickettsia rickettsii is a gram-negative, intracellular, coccobacillus bacterium that is around 0.8 to 2.0 micrometers long. R. rickettsi is the agent of Rocky Mountain spotted fever. R. rickettsii is one of the most pathogenic Rickettsia strains known to humans and affects a large majority of the Western Hemisphere, Rocky Mountain spotted fever first emerged in the Idaho Valley in 1896. At that time, not much information was known about the disease, the first clinical description of Rocky Mountain Spotted Fever was reported in 1899 by Edward E. Maxey. Howard Ricketts, a professor of pathology at the University of Chicago in 1902, was the first to identify. At this time, the trademark rash now began to emerge in the western Montana area. His research entailed interviewing victims of the disease and collecting and studying infected animals and he was also known to inject himself with pathogens to measure their effects. Unfortunately, his research was cut short after his death from an insect bite. S. Burt Wolbach is credited for the first detailed description of the agent that causes R. rickettsii in 1919. He clearly recognized it as a bacterium which was seen most frequently in endothelial cells. The most common hosts for the R. rickettsii bacteria are ticks, ticks that carry R. rickettsia fall into the family of Ixodidae ticks, also known as hard bodied ticks. Ticks are vectors, reservoirs and amplifiers of this disease, there are currently three known tick specifics that commonly carry R. rickettsii. American dog tick Rocky Mountain Wood Tick Brown dog tick, ticks can contract R. rickettsii by many means. Once a tick becomes infected with this pathogen, they are infected for life, in addition, an infected male tick can transmit the organism to an uninfected female during mating. Once infected, the tick can transmit the infection to her offspring. Due to its confinement in the midgut and small intestine, Rickettsia rickettsii can be transmitted to mammals, transmission to mammals can occur in multiple ways. One way of contraction is through the contact of infected host feces to an uninfected host, if infected host feces comes into contact with an open skin wound, it is possible for the disease to be transmitted. Additionally, an uninfected host can become infected with R. rickettsii when eating food that contains the feces of the infected vector, another way of contraction is by the bite of an infected tick
7.
Mite
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Mites, along with ticks, are small arthropods belonging to the subclass Acari and the class Arachnida. The scientific discipline devoted to the study of ticks and mites is called acarology, in soil ecosystems, mites are favored by high organic matter content and by moist conditions, wherein they actively engage in the fragmentation and mixing of organic matter. Mites are among the most diverse and successful of all the invertebrate groups and they have exploited an incredible array of habitats, and because of their small size, go largely unnoticed. Many live freely in the soil or water, but there are also a number of species that live as parasites on plants, animals. It is estimated that 48,200 species of mites have been described, mites occupy a wide range of ecological niches. For example, Oribatida mites are important decomposers and occur in many habitats and they eat a wide variety of material including living and dead plant and fungal material, lichens and carrion, some are even predatory, though no species of Oribatida mite are parasites. Many mites which have well studied are parasitic on plants. One family of mites Pyroglyphidae, or nest mites, live primarily in the nests of birds and these mites are largely parasitic and consume blood, skin and keratin. Dust mites, which feed mostly on dead skin and hair shed from humans instead of consuming them from the organism directly, insects may also be infested by parasitic mites. Examples are Varroa destructor, which attaches to the body of the bee, and Acarapis woodi. There are hundreds of species of associated with other bee species. They attach to the bees in a variety of ways, for example, Trigona corvina workers have been found with mites attached to the outer face of their hind tibiae. Some are thought to be parasites, while others are beneficial symbionts, mites also parasitize some ant species, such as Eciton burchellii. Some of the plant pests include the spider mites, thread-footed mites. Among the species that attack animals are members of the sarcoptic mange mites, demodex mites are parasites that live in or near the hair follicles of mammals, including humans. Acari are mites, except for the three families of ticks, mites also hold the record speed, for its length, Paratarsotomus macropalpis is the fastest animal on Earth. The majority of species are harmless to humans, but a few species of mites can colonize humans directly, act as vectors for disease transmission. Mites which colonize human skin are the cause of several types of skin rashes, such as grain itch, grocers itch
8.
Orientia tsutsugamushi
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Orientia tsutsugamushi is the causative organism of scrub typhus, and the natural vector and reservoir is probably trombiculid mites. The organism is an intracellular pathogen, which needs to infect eukaryotic cells in order to multiply. The envelope is similar to that of Gram negative bacteria, but it is not easily stained with Gram stain, genetic methods have revealed even greater complexity than had been previously described. Infection with one serotype does not confer immunity to other serotypes, repeated infection in the same individual is therefore possible, and this complicates vaccine design. The bacterium was initially categorised in the genus Rickettsia, but is now classed in a genus, Orientia. It is 0.5 µm wide and 1.2 to 3.0 µm long, the organism is highly virulent and should only be handled in a laboratory with biosafety level 3 facilities. O. tsutsugamushi is sensitive in vitro to doxycycline, rifampicin and azithromycin and it is innately resistant to all β-lactam antibiotics because it lacks a classical peptidoglycan cell wall. Aminoglycosides are also ineffective in human infection because the organism is intracellular, there are currently no licensed scrub typhus vaccines available. It is now known there is enormous antigenic variation in Orientia tsutsugamushi strains. Any scrub typhus vaccine should give protection to all the strains present locally, a vaccine developed for one locality may not be protective in another locality, because of antigenic variation. This complexity continues to hamper efforts to produce a viable vaccine
. PMID 16223955.
