North Wilkesboro is a town in Wilkes County, North Carolina, United States. The population was 4,131 at the 2020 US Census. North Wilkesboro is the birthplace and original home of Lowe's Home Improvement, which continues to have a major presence in the community. The town is also known as one of the birthplaces of the sport of stock-car racing, and the North Wilkesboro Speedway was the first NASCAR-sanctioned track. Due to the town's proximity to the nearby Blue Ridge Mountains and its numerous tourist venues, North Wilkesboro has been nicknamed the "Key to the Blue Ridge".

Wilkes County is a county located in the U.S. state of North Carolina. It is a part of the state's western mountain region. As of the 2020 census the population was 65,969. Its county seat is Wilkesboro, and its largest community is North Wilkesboro. Wilkes County comprises the North Wilkesboro, NC Micropolitan Statistical Area.