The Northern Region is one of the sixteen regions of Ghana. It is situated in the northern part of the country and ranks as the second largest of the sixteen regions. Before its division, it covered an area of 25,000 square kilometres, representing 10 percent of Ghana's area. In December 2018, the Savannah Region and North East Region were created from it. The Northern Region is divided into 16 districts. The region's capital is Tamale, Ghana's third largest city.

Ghana, officially the Republic of Ghana, is a country in West Africa. It abuts the Gulf of Guinea and the Atlantic Ocean to the south, sharing a border with Ivory Coast in the west, Burkina Faso in the north, and Togo in the east. Ghana covers an area of 239,567 km2 (92,497 sq mi), spanning diverse biomes that range from coastal savannas to tropical rainforests. With over 32 million inhabitants, Ghana is the second-most populous country in West Africa. The capital and largest city is Accra; other significant cities include Kumasi, Tamale, and Sekondi-Takoradi.