Olive Branch is the 6th most populous city in Mississippi, US, located in DeSoto County. At the 2020 census the population was 39,711. Olive Branch is part of the Memphis Metropolitan Statistical Area, a region that consists of three counties in southwest Tennessee, five counties in northwest Mississippi, and two counties in eastern Arkansas. Olive Branch was the fastest-growing city in the United States, with a growth rate of 838% as of 2010 in a thirty year time frame. Along with other rapidly growing places in DeSoto County, Olive Branch attributes most of its growth and development to the exodus of large numbers of families from central Memphis.

DeSoto County is a county located on the northwestern border of the U.S. state of Mississippi. As of the 2020 census, the population was 185,314, making it the third-most populous county in Mississippi. Its county seat is Hernando.