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Jeff Dawson

Jeff Dawson is a Canadian record producer, songwriter and mixer. Vancouver-based Jeff Dawson developed and produced the breakthrough self-titled second album for Daniel Powter. After working on Daniel's songs and helping develop the project's sound over 3 years, Warner Bros. Chairman/CEO Tom Whalley took one knew he had something extraordinary. Daniel's single "Bad Day" was #1 for 5 weeks on Billboard Hot 100 of 2006 and has become an incredible worldwide hit with 2.2 million downloads and nearly 3 million albums sold. Dawson produced State of Shock's hit single Money Honey cementing Top 10 status at multiple Canadian radio formats, including Rock, CHR, Hot AC. Along with becoming the #1 most played/requested song at Satellite radio selling 40,000 copies prior to its US release, surpassing platinum status for digital sales with over 51,000 sold, Money Honey held down the #1 post on the Canadian all formats Radio Chart for two months, spending close to a year on the Canadian Billboard Hot 100 singles Chart.

He has worked with Marcy Playground, State of Shock, The Dudes, Holly McNarland and Tal Bachman. Daniel Powter, Bad Day Daniel Powter, Daniel Powter Stars Of Boulevard, You Can Take The Money The Dudes, Blood Guts Bruises Cuts State of Shock, Love & Lies Kelly Rowland, Unity Incura, The Greatest Con Holly McNarland, Chin-Up Buttercup 5AM, Raise The Sun Eileen Rothe, Dream Girl Tal Bachman Kristina Antuna, "Mr. Sun" Crystal Cote, Love Andrew Allen The Goodluck Assembly, "Find Me Out" Justine Bennett, Invisible Nas Art Of Dying Brandon Paris Band Beyond The Fall, A Day In The Death Of Mark Huculak Splitting Adam Birds Of Wales Corey Lee, Sinful Innocence Downtyme, Said And Done Crystal Pistol, Crystal Pistol Kuba Rick Threat Chantelle Marie, Chantelle Marie Lily Frost, Lunamarium D-Cru, The Outer World Exit This Side, Wasted Brundlefly, Locked In This House Pierer Legault, Restoration Janet Panic, The Girl Who Passed For Normal Mr. Underhill, Mr. Underhill Ralph Alphonso, This Is For The Night People The Cartels Kinnie Star Helenkeller Michael Behm Templar Skunk Anansie Rykka, The Last of Our Kind Credits at Credits at Credits at Official website

Primary sclerosing cholangitis

Primary sclerosing cholangitis is a long-term progressive disease of the liver and gallbladder characterized by inflammation and scarring of the bile ducts which allow bile to drain from the gallbladder. Affected individuals may have no symptoms or may experience signs and symptoms of liver disease such as yellow discoloration of the skin and eyes and abdominal pain; the bile duct scarring which occurs in PSC narrows the ducts of the biliary tree and impedes the flow of bile to the intestines. It can lead to cirrhosis of the liver and liver failure. PSC increases the risk of various cancers including liver cancer, gallbladder carcinoma, colorectal cancer, cholangiocarcinoma; the underlying cause of PSC is unknown. Genetic susceptibility, immune system dysfunction, abnormal composition of the gut flora may play a role; this is further suggested by the observation that 75% of individuals with PSC have inflammatory bowel disease, most ulcerative colitis. There is no effective medical treatment for primary sclerosing cholangitis.

The most definitive treatment for PSC is a liver transplant but it can recur after transplantation. Many people affected by PSC require a liver transplant. PSC is a rare disease and most affects people with IBD. 3–7.5% of people with ulcerative colitis have PSC and 80% of people with PSC have some form of IBD. Diagnosis occurs in younger people in their 30s or 40s. Individuals of Northern European ancestry are affected more than people of Southern European or Asian descent. Men are affected more than women; the disease was described in the mid-1800s but was not characterized until the 1970s with the advent of improved medical imaging techniques such as endoscopic retrograde cholangiopancreatography. Nearly half of people with PSC do not have symptoms and are incidentally discovered to have PSC due to abnormal liver function tests, but a substantial proportion will have debilitating signs and symptoms of the disease. Signs and symptoms of PSC may include severe non-specific fatigue. Yellowing of the skin and white portion of the eyes may be seen.

Enlargement of the liver and spleen are seen in 40% of affected individuals. Abdominal pain affects about 20% of people with PSC. Multiple episodes of life-threatening acute cholangitis can be seen due to impaired drainage of the bile ducts, which increases the risk of infection. Dark urine due to excess conjugated bilirubin, water-soluble and excreted by the kidneys Malabsorption of fat, steatorrhea, due to an inadequate amount of bile reaching the small intestine, leading to decreased levels of the fat-soluble vitamins, A, D, E, K. Portal hypertension, a complication of cirrhosis, which can manifest with esophageal and parastomal varices as well as hepatic encephalopathy; the exact cause of primary sclerosing cholangitis is unknown and its pathogenesis is poorly understood. Although PSC is thought to be an autoimmune disease, it does not demonstrate a clear response to immunosuppressants. Thus, many experts believe it to be a complex, multifactorial disorder and one that encompasses several different hepatobiliary diseases.

Data have provided novel insights suggesting: an important association between the intestinal microbiota and PSC and a process referred to as cellular senescence and the senescence-associated secretory phenotype in the pathogenesis of PSC. In addition, there are longstanding, well-recognized associations between PSC and human leukocyte antigen alleles. PSC is characterized by inflammation of the bile ducts with consequent stricturing and hardening of these ducts due to scar formation, be it inside and/or outside the liver; the resulting scarring of the bile ducts obstructs the flow of bile, which further perpetuates bile duct and liver injury. Chronic impairment of bile flow due to blockage and dysfunctional bile transport causes progressive biliary fibrosis and biliary cirrhosis and liver failure; the primary physiological function of bile is to assist in the breakdown and absorption of fat in the intestinal tract. Liver enlargement is seen due to portal hypertension caused by compression of portal veins by the proximate sclerosed intrahepatic bile ducts, leads to right upper quadrant abdominal pain.

PSC is diagnosed on the basis of having at least two of three clinical criteria after secondary causes of sclerosing cholangitis have been ruled out: serum alkaline phosphatase > 1.5x the upper limit of normal for longer than 6 months. A cholangiogram would be obtained via endoscopic retrograde cholangiopancreatography, which reveals "beading" of the bile ducts inside and/or outside the liver; the preferred option for diagnostic cholangiography, given its non-invasive yet accurate nature, is magnetic resonance cholangiopancreatography, a magnetic resonance imaging technique. MRCP has unique strengths, including high spatial resolution, can be used to visualize the biliary tract of small animal models of PSC. Most people with PSC have evidence of

Otoyol 30

Otoyol 30 known as the Izmir Beltway and abbreviated as the O-30, is a 51 km long motorway that runs around the Gulf of Izmir from Balçova to Çiğli. The motorway acts as a bypass for through-traffic around the city and connects to four other motorways. For most of its route, the O-30 runs along the perimeter of Izmir, but enters urbanized areas in Balçova, Karşıyaka and Çiğli; the entire motorway has six lanes and is a part of the E87 and E881. The first section of the O-30 opened to traffic in 1993 with the most recent section opened in 2008. Construction of the O-30 was started in 1988 in order to relive traffic on the congested D-550, the only direct north-south road at the time. Along with relieving inner-city congestion, the O-30 was planned to be a connecting hub for two other motorways under construction at the time; the first section of the motorway was opened to traffic on 12 December 1993, between Karabağlar and Işıkkent. This 18 km long section provided an alternate route around the city from Gaziemir to Bornova as well as connecting to the O-31, which opened its first section on the same day.

Construction of the O-30 slowed down over the next years, due to financial difficulties. Construction of the southern half of the O-30 progressed faster than construction of the northern half. On 10 July 1997, the O-30 was connected to the D-300, the main east-west trunk road and on 15 August 1998, the 2.5 km long section between Karabağlar and Uzundere was opened to traffic. In 1999, connection to the Izmir Bus Terminal was opened on the 10 April, followed by the 5 km long section between Uzundere and Balçova, opened on 30 April; the motorway was connected to the O-32 on 6 August 2002, via a 1.5 km viaduct through Balçova, thus completing the southern half of the O-30. Due to the slow progression of its northern half, the O-30 was nicknamed the motorway that will never open and residents of Izmir started to protest the delay. Construction was sped up in 2006 and in January 2007 the 12.6 km section between Bornova and Karşıyaka along with two tunnels was opened. Construction progressed at a steady pace over the next years as the O-30 was extended from Karşıyaka to Çiğli on 15 June 2008.

List of highways in Turkey

Billy Carlson

Billy Carlson was an American racecar driver. He was killed in an AAA National Championship race at Tacoma Speedway. Billy Carlson began his career competing in races on the Pacific coast and was a comparative unknown before he started in the 500-mile classic at Indianapolis in 1914, he took ninth in the event and "immediately attained prominence on the gasoline circuit."He was a member of the Maxwell team for two years in 1914 and 1915 after he was "discovered" by Ray Harroun, a Maxwell engineer. His most notable achievement after joining Maxwell was his world's non-stop record of 305 miles made at San Diego, California, in January 1915, he came in second to Barney Oldfield at California. Carlson sustained fatal injuries in the Montamarathon race at Tacoma Speedway on July 4, 1915. Maxwell suspended their racing game for the remainder of the season and the team was disbanded and the automobiles were shipped back to the factory in Detroit

The Bee Gees Sing and Play 14 Barry Gibb Songs

The Bee Gees Sing and Play 14 Barry Gibb Songs is the debut studio album by the English-Australian pop group the Bee Gees. It was released in November 1965 on the Australian Leedon label, it is a compilation of most of the Gibb brothers' singles, released over the previous three years in Australia, which accounts for the many different styles of music on it. Only five new songs were recorded for the album: "I Was a Lover, a Leader of Men", "And the Children Laughing", "I Don't Think It's Funny", "How Love Was True" and "To Be or Not to Be". Barry had more than enough unrecorded songs for an all new-LP, but the rest of the album was instead made up of nine lesser-known singles. Bill Shepherd set the order of the songs. Barry plays rhythm guitar, Maurice plays the other guitars, like the leads in "I Was a Lover, a Leader of Men" and "How Love Was True", whether Maurice managed to play the acoustic lead guitar in "I Don't Think It's Funny" or the fast piano in "To Be or Not to Be" is less certain, the organ on "I Was a Lover, a Leader of Men" and "And the Children Laughing" is either Robin or Maurice.

Though uncredited on the back of this album, it is confirmed that the Gibbs' friend Trevor Gordon played lead guitar on "Peace of Mind", "Wine and Women" and "Follow the Wind". Gordon released several recordings under the name Trevor Gordon and the Bee Gees. Gordon went on to find success with Graham Bonnet in the UK-based duo the Marbles, who had a hit with "Only One Woman" written by the Bee Gees and produced by Barry and Maurice with Robert Stigwood; the original issue of the LP on Leedon is rare. The reissue in 1967 on the Calendar label is seen in Australia; this album package was not issued elsewhere and was not issued on CD until it was released as part of a 2013 box set called Festival Album Collection: 1965-1967. Curiously, the "Bee Gees" are spelled with an apostrophe on the front cover, but not on the rear sleeve or labels – and unlike on any of their single releases. Earlier tracks, like "Peace of Mind", "Claustrophobia" and "Could It Be", are in the Merseybeat vein, popular throughout 1964, while singles like "Follow the Wind" and "And the Children Laughing" reflect the more folky sounds of 1965.

Of the new tracks that were recorded for the album, "To Be or Not to Be" was the biggest departure, being a blues-based hard rocker. In the compilation Brilliant from Birth, "You Wouldn't Know" is faded early to 2:03, losing the shouting and laughing in the longer and original fade. All tracks are written by Barry Gibb. Bee GeesBarry Gibb – lead and backing vocals, rhythm guitar Robin Gibb – lead and backing vocals, melodica on "Claustrophobia" and "Could It Be" Maurice Gibb – harmony and backing vocals, lead guitar, organAdditional musicians and productionBruce Davis – lead guitar on "Claustrophobia" and "Could It Be" Leith Ryan – lead guitar on "Claustrophobia" and "Could It Be" Bill Swindells – bass on "Claustrophobia" and "Could It Be" Laurie Wardman – drums on "Claustrophobia" and "Could It Be" Trevor Gordon – lead guitar on "Follow The Wind," "Wine & Women" and "Peace of Mind" Uncredited musicians – bass, violin, piano on "Timber!" and "Take Hold of That Star"