Oxford Street is a major thoroughfare in Sydney, New South Wales, Australia, running from the south-east border of the Sydney central business district to Bondi Junction in the Eastern Suburbs. Close to the CBD in particular, the street is lined with numerous shops, bars and nightclubs. After the 1980s, Oxford Street garnered a reputation as Sydney's primary nightclub strip and subsequently saw a large increase in the number of crimes committed in the area. However, the 2014 lockout laws saw many nightclubs close and the crime rate drop as Sydney's nightlife hubs moved to Darling Harbour and Newtown. The lockout laws ended in 2020 with a focus on small bars and restaurants. Many nightclubs reopened in 2021 especially around Taylor Square.

The Sydney central business district (CBD) is the historical and main commercial centre of Sydney. The CBD is Sydney's city centre, or Sydney City, and the two terms are used interchangeably. Colloquially, the CBD or city centre is often referred to simply as "Town" or "the City". The Sydney city centre extends southwards for about 3 km (2 mi) from Sydney Cove, the point of first European settlement in which the Sydney region was initially established.