PLCB4

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PLCB4
Identifiers
AliasesPLCB4, ARCND2, PI-PLC, phospholipase C beta 4
External IDsMGI: 107464 HomoloGene: 8471 GeneCards: PLCB4
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for PLCB4
Genomic location for PLCB4
Band20p12.3-p12.2Start9,068,763 bp[1]
End9,481,242 bp[1]
RNA expression pattern
PBB GE PLCB4 203895 at fs.png

PBB GE PLCB4 203896 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000933
NM_001172646
NM_182797

NM_013829
NM_001355153
NM_001355154
NM_001355155
NM_001355156

RefSeq (protein)

NP_000924
NP_001166117
NP_877949

n/a

Location (UCSC)Chr 20: 9.07 – 9.48 MbChr 2: 135.66 – 136.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 is an enzyme that in humans is encoded by the PLCB4 gene.[5][6]

Function[edit]

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Two transcript variants encoding different isoforms have been found for this gene.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101333 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039943 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Alvarez RA, Ghalayini AJ, Xu P, Hardcastle A, Bhattacharya S, Rao PN, Pettenati MJ, Anderson RE, Baehr W (Feb 1996). "cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4)". Genomics. 29 (1): 53–61. doi:10.1006/geno.1995.1214. PMID 8530101. 
  6. ^ a b "Entrez Gene: PLCB4 phospholipase C, beta 4". 

Further reading[edit]