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Protein PLCE1 PDB 2bye.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesPLCE1, NPHS3, PLCE, PPLC, phospholipase C epsilon 1
External IDsMGI: 1921305 HomoloGene: 9478 GeneCards: PLCE1
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for PLCE1
Genomic location for PLCE1
Band10q23.33Start94,030,812 bp[1]
End94,332,823 bp[1]
RNA expression pattern
PBB GE PLCE1 205112 at fs.png

PBB GE PLCE1 205111 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 10: 94.03 – 94.33 MbChr 19: 38.48 – 38.79 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1 is an enzyme that in humans is encoded by the PLCE1 gene.[5][6][7]


PLCE1 belongs to the phospholipase family that catalyzes the hydrolysis of polyphosphoinositides such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) to generate the second messengers Ins(1,4,5)P3 and diacylglycerol. These products initiate a cascade of intracellular responses that result in cell growth and differentiation and gene expression.[supplied by OMIM][7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138193 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024998 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Lopez I, Mak EC, Ding J, Hamm HE, Lomasney JW (May 2001). "A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway". J Biol Chem. 276 (4): 2758–65. doi:10.1074/jbc.M008119200. PMID 11022047. 
  6. ^ Song C, Hu CD, Masago M, Kariyai K, Yamawaki-Kataoka Y, Shibatohge M, Wu D, Satoh T, Kataoka T (May 2001). "Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras". J Biol Chem. 276 (4): 2752–7. doi:10.1074/jbc.M008324200. PMID 11022048. 
  7. ^ a b "Entrez Gene: PLCE1 phospholipase C, epsilon 1". 

Further reading[edit]

  • Jefferson JA, Shankland SJ (2007). "Familial nephrotic syndrome: PLCE1 enters the fray". Nephrol. Dial. Transplant. 22 (7): 1849–52. doi:10.1093/ndt/gfm098. PMID 17449496. 
  • Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852Freely accessible. PMID 1979339. 
  • Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". Eur. J. Immunol. 25 (9): 2695–700. doi:10.1002/eji.1830250944. PMID 7589147. 
  • Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385. 
  • Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92. doi:10.1159/000026336. PMID 9730685. 
  • Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74. doi:10.1046/j.1471-4159.1999.0731363.x. PMID 10501179. 
  • Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331. 
  • Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712. 
  • Jin TG, Satoh T, Liao Y, Song C, Gao X, Kariya K, Hu CD, Kataoka T (2001). "Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling". J. Biol. Chem. 276 (32): 30301–7. doi:10.1074/jbc.M103530200. PMID 11395506. 
  • Schmidt M, Evellin S, Weernink PA, von Dorp F, Rehmann H, Lomasney JW, Jakobs KH (2001). "A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase". Nat. Cell Biol. 3 (11): 1020–4. doi:10.1038/ncb1101-1020. PMID 11715024. 
  • Evellin S, Nolte J, Tysack K, vom Dorp F, Thiel M, Weernink PA, Jakobs KH, Webb EJ, Lomasney JW, Schmidt M (2002). "Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B". J. Biol. Chem. 277 (19): 16805–13. doi:10.1074/jbc.M112024200. PMID 11877431. 
  • Song C, Satoh T, Edamatsu H, Wu D, Tadano M, Gao X, Kataoka T (2002). "Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon". Oncogene. 21 (53): 8105–13. doi:10.1038/sj.onc.1206003. PMID 12444546. 
  • Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669. 
  • Czyzyk J, Brogdon JL, Badou A, Henegariu O, Preston Hurlburt P, Flavell R, Bottomly K (2003). "Activation of CD4 T cells by Raf-independent effectors of Ras". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6003–8. doi:10.1073/pnas.1031494100. PMC 156316Freely accessible. PMID 12721365. 
  • Lennartsson J, Wernstedt C, Engström U, Hellman U, Rönnstrand L (2003). "Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk". Exp. Cell Res. 288 (1): 110–8. doi:10.1016/S0014-4827(03)00206-4. PMID 12878163. 
  • vom Dorp F, Sari AY, Sanders H, Keiper M, Oude Weernink PA, Jakobs KH, Schmidt M (2005). "Inhibition of phospholipase C-epsilon by Gi-coupled receptors". Cell. Signal. 16 (8): 921–8. doi:10.1016/j.cellsig.2004.01.009. PMID 15157671.