PMM1

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PMM1
Protein PMM1 PDB 2fuc.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PMM1, Sec53, phosphomannomutase 1
External IDs MGI: 1353418 HomoloGene: 90898 GeneCards: PMM1
Gene location (Human)
Chromosome 22 (human)
Chr. Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for PMM1
Genomic location for PMM1
Band 22q13.2 Start 41,576,894 bp[1]
End 41,589,890 bp[1]
RNA expression pattern
PBB GE PMM1 203467 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002676

NM_001282040
NM_001282041
NM_013872

RefSeq (protein)

NP_002667

NP_001268969
NP_001268970
NP_038900

Location (UCSC) Chr 22: 41.58 – 41.59 Mb Chr 22: 81.95 – 81.96 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phosphomannomutase 1 is an enzyme that in humans is encoded by the PMM1 gene.[5][6][7]

Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol (GPI) anchored proteins.[7]

This enzyme has been extracted from the venom of the wasp species Polistes major major.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100417 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022474 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Matthijs G, Schollen E, Pirard M, Budarf ML, Van Schaftingen E, Cassiman JJ (Jun 1997). "PMM (PMM1), the human homologue of SEC53 or yeast phosphomannomutase, is localized on chromosome 22q13". Genomics. 40 (1): 41–7. doi:10.1006/geno.1996.4536. PMID 9070917. 
  6. ^ Pirard M, Collet JF, Matthijs G, Van Schaftingen E (Sep 1997). "Comparison of PMM1 with the phosphomannomutases expressed in rat liver and in human cells". FEBS Lett. 411 (2–3): 251–4. doi:10.1016/S0014-5793(97)00704-7. PMID 9271215. 
  7. ^ a b "Entrez Gene: PMM1 phosphomannomutase 1". 
  8. ^ ČeŘovský V (2007). "Identification of three novel peptides isolated from the venom of the neotropical social wasp Polistes major major". Journal of Peptide Science. 13: 445–450. doi:10.1002/psc.860. 

Further reading[edit]