Pentalenene synthase

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pentalenene synthase
EC number
CAS number 90597-46-9
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a pentalenene synthase (EC is an enzyme that catalyzes the chemical reaction

2-trans,6-trans-farnesyl diphosphate pentalenene + diphosphate

Hence, this enzyme has one substrate, 2-trans,6-trans-farnesyl diphosphate, and two products, pentalenene and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, pentalenene-forming). This enzyme is also called pentalenene synthetase.


  • Cane DE (1983). "Cell-free studies of monoterpene and sesquiterpene biosynthesis". Biochem. Soc. Trans. 11 (5): 510–5. PMID 6642060. 
  • Cane DE, Tillman AM (1983). "Pentalenene biosynthesis and the enzymic cyclization of farnesyl pyrophosphate". J. Am. Chem. Soc. 105: 122–124. doi:10.1021/ja00339a026. 
  • Cane, DE, Hubbard BR; Sohng, JK; Lamberson, CR; Rudnicki, SM; Wu, Z; Lloyd, MD; Oliver, JS; Hubbard, BR (1994). "Pentalenene synthase. Purification, molecular cloning, sequencing, and high-level expression in Escherichia coli of a terpenoid cyclase from Streptomyces UC5319". Biochemistry. 33 (19): 5846–57. doi:10.1021/bi00185a024. PMID 8180213.