Pentalenic acid synthase

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Pentalenic acid synthase
Identifiers
EC number 1.14.15.11
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Pentalenic acid synthase (EC 1.14.15.11, CYP105D7, sav7469 (gene)) is an enzyme with systematic name 1-deoxypentalenate,reduced ferredoxin:O2 oxidoreductase.[1] This enzyme catalyses the following chemical reaction

1-deoxypentalenate + reduced ferredoxin + O2 pentalenate + oxidized ferredoxin + H2O

Pentalenic acid synthase is a heme-thiolate enzyme (P-450).

References[edit]

  1. ^ Takamatsu, S.; Xu, L.H.; Fushinobu, S.; Shoun, H.; Komatsu, M.; Cane, D.E.; Ikeda, H. (2011). "Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis". J. Antibiot. (Tokyo). 64 (1): 65–71. doi:10.1038/ja.2010.135. PMC 3030646. PMID 21081950.

External links[edit]