Phenylacetaldoxime dehydratase

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Phenylacetaldoxime dehydratase
Identifiers
EC number4.99.1.7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

In enzymology, a phenylacetaldoxime dehydratase (EC 4.99.1.7) is an enzyme that catalyzes the chemical reaction

(Z)-phenylacetaldehyde oxime phenylacetonitrile + H2O

Hence, this enzyme has one substrate, (Z)-phenylacetaldehyde oxime, and two products, phenylacetonitrile and H2O.

This enzyme belongs to the family of lyases, specifically the "catch-all" class of lyases that do not fit into any other sub-class. The systematic name of this enzyme class is (Z)-phenylacetaldehyde-oxime hydro-lyase (phenylacetonitrile-forming). Other names in common use include PAOx dehydratase, arylacetaldoxime dehydratase, OxdB, and (Z)-phenylacetaldehyde-oxime hydro-lyase. This enzyme participates in styrene degradation.

References[edit]

  • Kato Y, Nakamura K, Sakiyama H, Mayhew SG, Asano Y (2000). "Novel heme-containing lyase, phenylacetaldoxime dehydratase from Bacillus sp. strain OxB-1: purification, characterization, and molecular cloning of the gene". Biochemistry. 39 (4): 800&ndash, 9. doi:10.1021/bi991598u. PMID 10651646.
  • Kobayashi K, Yoshioka S, Kato Y, Asano Y, Aono S (2005). "Regulation of aldoxime dehydratase activity by redox-dependent change in the coordination structure of the aldoxime-heme complex". J. Biol. Chem. 280 (7): 5486&ndash, 90. doi:10.1074/jbc.M410474200. PMID 15596434.