Phenylbiguanide

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Phenylbiguanide
1-Phenylbiguanide.svg
Legal status
Legal status
  • UN: Unscheduled
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
Chemical and physical data
Formula C8H11N5
Molar mass 177.206
3D model (JSmol)
Melting point 135–142 °C (275–288 °F)

Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system.[1] It has been found to trigger dopamine release in the nucleus accumbens of rats.[2]

Derivatives[edit]

References[edit]

  1. ^ Higgins, GA; Joharchi, N; Sellers, EM (1993), "Behavioral effects of the 5-hydroxytryptamine3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in rats.", J Pharmacol Exp Ther, Journal of Pharmacology and Experimental Therapeutics, 264: 1440–9, PMID 8450478 
  2. ^ Chen, JP; van Praag, HM; Gardner, EL (1991), "Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens.", Brain Res, Brain Research., 543: 354–7, doi:10.1016/0006-8993(91)90050-6, PMID 1711914