Phorbol-diester hydrolase

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phorbol-diester hydrolase
Identifiers
EC number3.1.1.51
CAS number81181-74-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a phorbol-diester hydrolase (EC 3.1.1.51) is an enzyme that catalyzes the chemical reaction

phorbol 12,13-dibutanoate + H2O phorbol 13-butanoate + butanoate

Thus, the two substrates of this enzyme are phorbol 12,13-dibutanoate and H2O, whereas its two products are phorbol 13-butanoate and butanoate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 12,13-diacylphorbate 12-acylhydrolase. Other names in common use include diacylphorbate 12-hydrolase, diacylphorbate 12-hydrolase, phorbol-12,13-diester 12-ester hydrolase, and PDEH.

References[edit]

  • Shoyab M, Warren TC, Todaro GJ (1981). "Isolation and characterization of an ester hydrolase active on phorbol diesters from murine liver". J. Biol. Chem. 256 (23): 12529&ndash, 34. PMID 6946062.