Phosphatidylcholine desaturase

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phosphatidylcholine desaturase
EC number1.3.1.35
CAS number59929-36-1
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a phosphatidylcholine desaturase (EC is an enzyme that catalyzes the chemical reaction

1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NAD+ 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + NADH + H+

Thus, the two substrates of this enzyme are 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine and NAD+, whereas its 3 products are 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine:NAD+ Delta12-oxidoreductase. Other names in common use include oleate desaturase, linoleate synthase, oleoyl-CoA desaturase, and oleoylphosphatidylcholine desaturase.


  • Pugh EL, Kates M (1975). "Characterization of a membrane-bound phospholipid desaturase system of candida lipolytica". Biochim. Biophys. Acta. 380 (3): 442&ndash, 53. doi:10.1016/0005-2760(75)90112-5. PMID 166662.
  • Slack CR, Roughan PG, Browse J (1979). "Evidence for an oleoyl phosphatidylcholine desaturase in microsomal preparations from cotyledons of safflower (Carthamus tinctorius) seed". Biochem. J. 179 (3): 649&ndash, 56. doi:10.1042/bj1790649. PMC 1186674. PMID 475773.
  • Stymne S, Appelqvist LA (1978). "The biosynthesis of linoleate from oleoyl-CoA via oleoyl-phosphatidylcholine in microsomes of developing safflower seeds". Eur. J. Biochem. 90 (2): 223&ndash, 9. doi:10.1111/j.1432-1033.1978.tb12594.x. PMID 710426.